2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. DJ-V-159

DJ-V-159 是G蛋白偶联受体家族C组6 A (GPRC6A) 的激动剂。

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DJ-V-159 Chemical Structure

DJ-V-159 Chemical Structure

CAS No. : 2253744-53-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥464
In-stock
5 mg ￥420
In-stock
10 mg ￥686
In-stock
50 mg ￥2415
In-stock
100 mg ￥3850
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

DJ-V-159 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).

IC50 & Target

GPRC6A[1].
体外研究
(In Vitro)

DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DJ-V-159 相关抗体:
体内研究
(In Vivo)

DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

502.37

Formula

C24H12F6N4O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (49.76 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9906 mL 9.9528 mL 19.9056 mL
5 mM 0.3981 mL 1.9906 mL 3.9811 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
8 to 10 weeks ago wild type C57BL/6 mice are fasted for 5 hours, injected ip with ${DJ-V-159} (10 mg/kg body weight), or Metformin (300 mg/kg body weight), or vehicle (95% PEG + 5% DMSO; 10 μL/g body weight). Blood glucose levels are measured at 0, 30, 60 and 90 minutes after injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

DJ-V-159 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9906 mL 9.9528 mL 19.9056 mL 49.7641 mL
5 mM 0.3981 mL 1.9906 mL 3.9811 mL 9.9528 mL
10 mM 0.1991 mL 0.9953 mL 1.9906 mL 4.9764 mL
15 mM 0.1327 mL 0.6635 mL 1.3270 mL 3.3176 mL
20 mM 0.0995 mL 0.4976 mL 0.9953 mL 2.4882 mL
25 mM 0.0796 mL 0.3981 mL 0.7962 mL 1.9906 mL
30 mM 0.0664 mL 0.3318 mL 0.6635 mL 1.6588 mL
40 mM 0.0498 mL 0.2488 mL 0.4976 mL 1.2441 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DJ-V-1592253744-53-3Androgen ReceptorInhibitorinhibitorinhibit

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产品名称：
DJ-V-159
目录号：
HY-114165
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