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Exendin-4 acetate  (Synonyms: 醋酸艾塞那肽; Exenatide acetate)

目录号: HY-13443A 纯度: 99.91%
COA 产品使用指南 技术支持

Exendin-4 acetate (Exenatide acetate) 是由39个氨基酸组成的多肽。它是长效的 glucagon-like peptide-1 受体激动剂,IC50 值为 3.22 nM。

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Custom Peptide Synthesis

Exendin-4 acetate Chemical Structure

Exendin-4 acetate Chemical Structure

CAS No. : 914454-01-6

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1 mg ¥900
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5 mg ¥1960
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10 mg ¥2910
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25 mg ¥4100
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Customer Review

Other Forms of Exendin-4 acetate:

MCE 顾客使用本产品发表的 50 篇科研文献

Proliferation Assay
RT-PCR

    Exendin-4 acetate purchased from MCE. Usage Cited in: Front Pharmacol. 2019 Oct 25;10:1230.  [Abstract]

    Exendin-4 or FSK treatment reduces ER stress-induced β-cell viability. INS-1 cells are incubated with THAP (0.5 μM), with Eexendin-4.

    Exendin-4 acetate purchased from MCE. Usage Cited in: Front Pharmacol. 2019 Oct 25;10:1230.  [Abstract]

    INS-1 cells are incubated with THAP (0.5 μM), H89, with Exendin-4 or FSK at indicated concentration for 24 h, then the IL-1β level is analyzed by qRT-PCR (n = 3).
    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.

    IC50 & Target

    IC50: 3.22 nM (glucagon-like peptide-1 receptor)[1]

    体外研究
    (In Vitro)

    在人脐静脉内皮细胞中,Exendin-4 以剂量依赖性方式显著增加 NO 生成、内皮 NO 合酶 (eNOS) 磷酸化和 GTP 环化水解酶 1 (GTPCH1) 水平[2]
    Exendin-4 对 MCF-7 乳腺癌细胞具有细胞毒作用,48 小时 IC50 为 5 μM[3]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    与对照组相比,ob/ob 小鼠接受低剂量和高剂量 Exendin-4 治疗后,其血清 ALT 水平均有所改善,血糖水平也得到降低,并计算出 HOMA 评分。在研究期的最后 4 周内,接受 Exendin-4 治疗的 ob/ob 小鼠的净体重增长显著减少[4]
    接受 Exendin-4 治疗的动物胰腺腺泡炎症更严重,细胞核固缩更严重,体重也显著低于对照组大鼠。Exendin-4 治疗与大鼠的瘦素水平降低以及 HOMA 值降低相关[5]
    艾塞那肽可引起大鼠胸主动脉剂量依赖性舒张,这种舒张作用由 GLP-1 受体诱发,主要由 H2S 介导,但也由 NO 和 CO 介导[6]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    分子量

    4246.62

    同用名

    醋酸艾塞那肽; Exenatide acetate

    Formula

    C186H286N50O62S

    CAS 号
    性状

    固体

    颜色

    White to off-white

    Sequence

    His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

    Sequence Shortening

    HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

    中文名称

    醋酸艾塞那肽

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Sealed storage, away from moisture and light, under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

    溶解性数据
    细胞实验: 

    DMSO 中的溶解度 : ≥ 66.66 mg/mL (15.70 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    H2O 中的溶解度 : 25 mg/mL (5.89 mM; 超声助溶)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 0.2355 mL 1.1774 mL 2.3548 mL
    5 mM 0.0471 mL 0.2355 mL 0.4710 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验:

    以下溶解方案,请直接配制工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂: PBS

      Solubility: 100 mg/mL (23.55 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.91%

    参考文献
    Animal Administration
    [4][5]

    Rats: 20 Sprague-Dawley male rats, ten of which are treated with exendin-4 (10 μg/kg) and ten of which are used as controls. The study period is 75 days. Serum and pancreatic tissue are removed for biochemical and histological study. Blood glucose, amylase, lipase and adipocytokines are compared between the two groups[5].

    Mice: The exendin-4 treatment groups are treated with 10 μg/kg every 24 hours for the first 14 days. This treatment is the induction phase. Respective control mice (lean and ob/ob) receive saline every 24 hours. After 14 days Exendin-4-treated mice are randomly divided into two groups: one group receives high dose exendin-4 (20 μg/kg) every 12 hours, while the second group continues with low dose exendin-4 (10 μg/kg) every 12 hours. The control mice continue to receive saline every 12 hours. The mice are weighed daily for the 60-day treatment period[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.2355 mL 1.1774 mL 2.3548 mL 5.8870 mL
    5 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1774 mL
    DMSO 10 mM 0.0235 mL 0.1177 mL 0.2355 mL 0.5887 mL
    15 mM 0.0157 mL 0.0785 mL 0.1570 mL 0.3925 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    Exendin-4 acetate
    目录号:
    HY-13443A
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