1. Apoptosis
  2. c-Myc
  3. IZCZ-3

IZCZ-3 

目录号: HY-111411
产品使用指南

IZCZ-3 是有效的 c-MYC 转录抑制剂,具有抗肿瘤活性。

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IZCZ-3 Chemical Structure

IZCZ-3 Chemical Structure

CAS No. : 2223019-53-0

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Description

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity[1].

IC50 & Target

c-MYC transcription[1]

In Vitro

IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC50s of 3.3, 2.1,4.1, and 4.2 μM, respectively). IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC50=15.9 μM) and mouse mesangial cells (IC50=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells[1].
IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner[1].

Cell Proliferation Assay[1]

Cell Line: SiHa, HeLa, Huh7, and A375 cancer cells (with overexpression of c-MYC protein) and in normal BJ fibroblasts and primary cultured mouse mesangial cells (with relatively low expression of c-MYC protein).
Concentration: 2.1 μM-15.9 μM
Incubation Time: 24 hours
Result: IC50s of 3.3, 2.1,4.1, and 4.2 μM for SiHa, HeLa, Huh7, and A375 cancer cells; IC50s of 15.9 μM and 15.6 μM for BJ fibroblasts and mouse mesangial cells.

Cell Cycle Analysis[1]

Cell Line: SiHa cells
Concentration: 0, 1.25, 2.5, and 5 μM
Incubation Time: 12 hours
Result: Induced an apparent accumulation of cells in the G0/G1 phase (increasing from 61% to 70%) in a dose-dependent manner.
In Vivo

IZCZ-3 (20, 10, and 5 mg/kg; intraperitoneally; every other day for 24 days) inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft[1].

Animal Model: BALB/c nude mice (5 weeks old) bearing SiHa human cervical squamous cancer xenograft model[1]
Dosage: 20, 10, and 5 mg/kg
Administration: Treated intraperitoneally; every other day for 24 days
Result: Treatment with 20, 10, and 5 mg/kg resulted in a significant reduction in tumor weight with tumor growth inhibition (TGI) of 69%, 64%, and 57%, respectively. Displayed time-dependent inhibition of tumor growth.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

715.93

Formula

C₄₆H₄₉N₇O

CAS No.

2223019-53-0

SMILES

CN(CC1)CCN1C2=CC=C(C3=C(C4=CC=C(N5CCN(C)CC5)C=C4)N=C(C6=CC(C(C=CC=C7)=C7N8CC)=C8C=C6)N3C9=CC=C(OC)C=C9)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
IZCZ-3
目录号:
HY-111411
需求量:

IZCZ-3

Cat. No.: HY-111411