2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Ifetroban

Ifetroban  (Synonyms: BMS-180291)

目录号: HY-105218 纯度: 99.65%
COA 产品使用指南 技术支持

Ifetroban (BMS-180291) 是一种具有口服活性的血栓素 A2 (TXA2) 或前列腺素 H2 (PGH2) 受体拮抗剂。Ifetroban 具有抗血小板活性，可抑制肿瘤细胞迁移，但不影响细胞增殖。Ifetroban 可用于心肌缺血、高血压、中风、血栓、心肌病的研究。

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Ifetroban Chemical Structure

Ifetroban Chemical Structure

CAS No. : 143443-90-7

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规格 价格 是否有货 数量
1 mg ￥2500
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Customer Review

Other Forms of Ifetroban:

Ifetroban 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Prostaglandin Receptor 亚型特异性产品:

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DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research[1][2][3][4].

IC50 & Target

TXA2/TP

 

体外研究
(In Vitro)

Ifetroban (CPI211) (100 nM; 48 h) results Tpr inhibition and potently blocks spontaneous metastasis from primary tumors, without affecting tumor cell proliferation, motility, or tumor growth in 4T1 cells (mouse mammary cancer)[2].
Ifetroban (100 nM; 6 h) strongly inhibits PKC substrate phosphorylation, and blocks agonist (U46619, HY-108566)-induced TPr diminution in human umbilical vein endothelial cells (HUVECs)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ifetroban 相关抗体:

Western Blot Analysis[2]

Cell Line: Mouse pulmonary microvascular endothelial cells (MPMECs) and human umbilical vein endothelial cells (HUVECs)
Concentration: 100 nM
Incubation Time: 6 hours
Result: Decreased the level of TPr protein and inhibited PKC substrate phosphorylation.

Immunofluorescence[2]

Cell Line: Mouse pulmonary microvascular endothelial cells (MPMECs) and human umbilical vein endothelial cells (HUVECs)
Concentration: 100 nM
Incubation Time: 6 hours
Result: Showed transendothelial migration of GFP+ 4T1 and MDA-MB-231 across mouse MPMECs and human HUVECs.
体内研究
(In Vivo)

Ifetroban (50 mg/kg/d; p.o.; 2 d prior to, through 28 d after tumor injection) decreases hematogenous metastasis of multiple cancer types without in mice model[2].
Ifetroban (50 mg/kg/d; p.o.; 12 d) does not affect primary tumor growth but decreases tumor vessels in mice with 4T1 (mouse mammary cancer)[2].
Ifetroban (BMS 180,291; 1 and 3 mg/kg, p.o.) inhibits aggregation and antagonizes TP-receptor in monekys. Ifetroban (3 mg/kg, i.v.) causes only marginal and transient hemodynamic effects in anesthetized African green monkeys[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic (nu/nu) Balb/C female mice injected with tumor cells: 4T1 (mouse mammary cancer), MDA-MB-231 (human breast cancer), MiaPaCa2 (human pancreatic cancer), and A549 (human lung cancer) model[2]
Dosage: 50 mg/kg; via 25 μL vehicle (4% sucrose in sterile water)
Administration: Oral gavage; pretreated before 2 days and treated 28 days later
Result: Decreased the percentage of mice harboring MDA-MB-231 lung metastases from 90% to 20%, and mice with A549 lung metastases from 60% to 10%.
Clinical Trial
分子量

440.53

同用名

BMS-180291

Formula

C25H32N2O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

伊非曲班
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (227.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2700 mL 11.3500 mL 22.6999 mL
5 mM 0.4540 mL 2.2700 mL 4.5400 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ifetroban 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2700 mL 11.3500 mL 22.6999 mL 56.7498 mL
5 mM 0.4540 mL 2.2700 mL 4.5400 mL 11.3500 mL
10 mM 0.2270 mL 1.1350 mL 2.2700 mL 5.6750 mL
15 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
20 mM 0.1135 mL 0.5675 mL 1.1350 mL 2.8375 mL
25 mM 0.0908 mL 0.4540 mL 0.9080 mL 2.2700 mL
30 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8917 mL
40 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.4187 mL
50 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1350 mL
60 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL
80 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7094 mL
100 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5675 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ifetroban143443-90-7BMS-180291伊非曲班BMS180291BMS 180291Prostaglandin Receptormyocardial ischemiahypertensionstrokethrombosiscardiomyopathyantiplateletmigration inhibitonInhibitorinhibitorinhibit

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