1. Epigenetics
  2. Histone Demethylase
  3. KDOAM-25

KDOAM-25 是有效,高选择性的组蛋白赖氨酸脱甲基酶 5 (KDM5) 抑制剂,对 KDM5A,KDM5B,KDM5C,KDM5D 的 IC50 分别为 71 nM,19 nM,69 nM,69 nM。KDOAM-25 可增加转录起始位点的整体 H3K4 甲基化,并损害多发性骨髓瘤 MM1S 细胞的增殖。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 KDOAM-25 citrate

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

KDOAM-25 Chemical Structure

KDOAM-25 Chemical Structure

CAS No. : 2230731-99-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

KDOAM-25 的其他形式现货产品:

Customer Review

Other Forms of KDOAM-25:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].

IC50 & Target

IC50: 71 nM (KDM5A), 19 nM (KDM5B), 69 nM (KDM5C), 69 nM (KDM5D)[1]

体外研究
(In Vitro)

KDOAM-25 inhibits most potently KDM5B with an IC50 of ∼50 μM and the other KDM5 family members at concentrations above 100 μM. KDOAM-25 shows no cellular activity on any of the other tested JmjC family members[1].
KDOAM-25 is able to reduce the viability of MM1S cells with an IC50 of ∼30 μM after a delay of 5-7 days[1].
KDOAM-25 treatment results in a G1 cell-cycle arrest with an increased proportion of MM1S in G1 and a decrease of the proportion of cells in G2 without an increase in the proportion of cells in the apoptotic sub-G1 phase[1].
KDOAM-25 (50 μM) increases with approximately twice as much H3K4me3 in in multiple myeloma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

307.39

Formula

C15H25N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

KDOAM-25 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
KDOAM-25
目录号:
HY-102047
需求量: