2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE5-IN-2

PDE5-IN-2 是一种有效、高度选择性、可口服的 PDE5 抑制剂，IC50 值为 0.31 nM，对 PDE2A，PDE10A，PDE4D2 和 PDE6C 的选择性相对较弱，IC50 值分别为 106，46，43，1.2 nM。抗肺动脉高压作用。

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PDE5-IN-2 Chemical Structure

PDE5-IN-2 Chemical Structure

CAS No. : 2244517-61-9

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PDE5-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity[1].

IC50 & Target[1]

PDE5A1

0.31 nM (IC50)

PDE6C

1.2 nM (IC50)

PDE4D2

43 nM (IC50)

PDE10A

46 nM (IC50)

PDE2A

106 nM (IC50)

体外研究
(In Vitro)

PDE5-IN-2 (Compound 3) has at least 1000-fold selectivity over PDE1B, PDE3A, PDE7A1, PDE8A1, and PDE9A2 (IC50s, >32 000 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PDE5-IN-2 相关抗体:
体内研究
(In Vivo)

PDE5-IN-2 (1.25 mg/kg, p.o.) shows anti-pulmonary arterial hypertension activity, decreases mean pulmonary artery pressure in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

491.52

Formula

C25H21N3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDE5-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE5-IN-22244517-61-9Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-112704
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