1. Apoptosis
  2. Apoptosis
  3. RIPGBM

RIPGBM 

目录号: HY-122910
产品使用指南

RIPGBM 是一种选择性的细胞凋亡 (apoptosis) 诱导剂,诱导多形性成胶质细胞瘤 (GBM) 癌症干细胞 (CSCs) 凋亡,EC50≤500 nM。

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RIPGBM Chemical Structure

RIPGBM Chemical Structure

CAS No. : 355406-76-7

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Description

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].

IC50 & Target

EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1]

In Vitro

RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

428.45

Formula

C₂₆H₂₁FN₂O₃

CAS No.

355406-76-7

SMILES

CC(N(C(C1=O)=C(NCC2=CC=CC=C2)C(C3=C1C=CC=C3)=O)CC4=CC=C(F)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
RIPGBM
目录号:
HY-122910
需求量:

RIPGBM

Cat. No.: HY-122910