2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine chloride dihydrochloride

S-Adenosyl-L-methionine chloride dihydrochloride  (Synonyms: S-Adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride)

目录号: HY-14614A 纯度: ≥75.0%
COA 产品使用指南 技术支持

S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine chloride dihydrochloride 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine chloride dihydrochloride 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine chloride dihydrochloride 可用于肝病和骨关节炎的研究。

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S-Adenosyl-L-methionine chloride dihydrochloride Chemical Structure

S-Adenosyl-L-methionine chloride dihydrochloride Chemical Structure

CAS No. : 86867-01-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥559
In-stock
5 mg ￥500
In-stock
10 mg ￥700
In-stock
25 mg ￥980
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100 mg   询价  

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S-Adenosyl-L-methionine chloride dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

体外研究
(In Vitro)

S-Adenosyl-L-methionine (300 µM, 24 或 48 h) chloride dihydrochloride 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞[4]。
S-Adenosyl-L-methionine (300 µM, 24 h) chloride dihydrochloride 减少 Cal-33 和 JHU-SCC-011 细胞的迁移[4]。
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) chloride dihydrochloride 通过调节 DNMTs 的表达保护 5‑FU 的抗癌作用[5]。
Methyl Group Donor 甲基供体 Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S-Adenosyl-L-methionine chloride dihydrochloride 相关抗体:

Apoptosis Analysis[4]

Cell Line: Cal-33 and JHU-SCC-011 cells
Concentration: 300 µM
Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

Western Blot Analysis[4]

Cell Line: Cal-33 and JHU-SCC-011 cells
Concentration: 300 µM
Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
体内研究
(In Vivo)

S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) chloride dihydrochloride 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为[6]。
S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) chloride dihydrochloride 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Valproic acid treated young mice[6]
Dosage: 30 mg/kg
Administration: p.o., for 3 days
Result: Alleviated most ASD like neurobehavioral symptoms.
Normalized the redox potential in the prefrontal cortex.
分子量

507.82

同用名

S-Adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride

Formula

C15H25Cl3N6O5S
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (196.92 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : ≥ 50 mg/mL (98.46 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9692 mL 9.8460 mL 19.6920 mL
5 mM 0.3938 mL 1.9692 mL 3.9384 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥75.0%

COA (291 KB)

产品使用指南 (1538 KB)
参考文献

S-Adenosyl-L-methionine chloride dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.9692 mL 9.8460 mL 19.6920 mL 49.2300 mL
5 mM 0.3938 mL 1.9692 mL 3.9384 mL 9.8460 mL
10 mM 0.1969 mL 0.9846 mL 1.9692 mL 4.9230 mL
15 mM 0.1313 mL 0.6564 mL 1.3128 mL 3.2820 mL
20 mM 0.0985 mL 0.4923 mL 0.9846 mL 2.4615 mL
25 mM 0.0788 mL 0.3938 mL 0.7877 mL 1.9692 mL
30 mM 0.0656 mL 0.3282 mL 0.6564 mL 1.6410 mL
40 mM 0.0492 mL 0.2462 mL 0.4923 mL 1.2308 mL
50 mM 0.0394 mL 0.1969 mL 0.3938 mL 0.9846 mL
60 mM 0.0328 mL 0.1641 mL 0.3282 mL 0.8205 mL
80 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6154 mL
DMSO 100 mM 0.0197 mL 0.0985 mL 0.1969 mL 0.4923 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Adenosyl-L-methionine chloride86867-01-8S-Adenosyl methionine chlorideAdemetionine chlorideAdoMet chlorideEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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