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Sardomozide  (Synonyms: CGP 48664; SAM-486A)

目录号: HY-13746
产品使用指南

摩尔计算器

Sardomozide 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC50 值为 5 nM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Sardomozide dihydrochloride 通常具有更好的水溶性和稳定性。

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Sardomozide Chemical Structure

Sardomozide Chemical Structure

CAS No. : 149400-88-4

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Sardomozide 的其他形式现货产品:

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Other Forms of Sardomozide:

Sardomozide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

IC50 & Target

IC50: 5 nM (SAMDC)[1]
体外研究
(In Vitro)

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sardomozide 相关抗体:
分子量

230.27

Formula

C11H14N6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay
[2]

The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Sardomozide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sardomozide149400-88-4CGP 48664 SAM-486ACGP48664CGP-48664OthersInhibitorinhibitorinhibit

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