1. GPCR/G Protein
  2. Glucagon Receptor

Semaglutide TFA 

目录号: HY-114118A 纯度: 98.24%
产品使用指南

Semaglutide TFA 是人胰高血糖素样肽-1 的一个长效类似物,是人胰高血糖素样肽-1 (GLP-1) 受体激动剂,临床上可用于治疗2 型糖尿病,是全球首个口服 GLP-1 降糖剂。

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Semaglutide TFA Chemical Structure

Semaglutide TFA Chemical Structure

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Size Price Stock Quantity
500 μg ¥1600 In-stock
1 mg ¥2600 In-stock
5 mg ¥9100 In-stock
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Other Forms of Semaglutide TFA:

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Description

Semaglutide TFA, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes.

IC50 & Target

GLP-1 receptor[1].

In Vitro

Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM[1]. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1[3.

In Vivo

The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs[1]. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to liraglutide in most parameters[2]. Semaglutide lowers blood glucose by stimulating the release of insulin and also lowers body weight[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

References
Animal Administration
[2]

Mice[2]
Male C57BL/6 mice 10 weeks old (20-25 g) are used throughout the study. Mice are randomized divided into six groups (n=12 per group) (i) control group treated with saline alone; (ii) liraglutide group treated with saline and liraglutide (25 nmol/kg ip. once daily for 7 days); (iii) Semaglutide group treated with saline and Semaglutide (25 nmol/kg ip. once daily for 7 days), (iv) MPTP group treated with MPTP alone (once daily 20 mg/kg ip. for 7 days); (v) MPTP (once daily 20 mg/kg ip. for 7 days) followed immediately by liraglutide treated group (25 nmol/kg ip. once daily for 7 days). (vi) MPTP (20 mg/kg ip. once daily for 7 days) followed immediately by Semaglutide treated group (25 nmol/kg ip. Once daily for 7 days). At the end of drug treatments, measure the behavioral changes, neuronal damage, inflammatory markers, and other biomarkers[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
SMILES

OC(C(F)(F)F)=O.[Semaglutide]

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
Semaglutide TFA
目录号:
HY-114118A
需求量:

Semaglutide TFA

Cat. No.: HY-114118A