Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s)  (Synonyms: 羧甲基纤维素钠; CMC-Na (Viscosity:5000-15000 mPa.s))

Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

Protocal for preparing 0.5% CMC-Na Solution
Measure 0.5g of dry CMC-Na and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution.
Under the condition of stirring and heating (50-65°C), adding CMC-Na slowly to ddH2O/0.9% Saline helps to accelerate dissolution.

Note
1.You must ensure that your CMC-Na solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.
2.Completely dissolution of CMC-Na may requires 4 hours or more longer.

In a pharmacological test, CMC-Na (oral;5% in water; 1 year) is well tolerated in rats^[2].
In an acute oral toxicity study in female mice, LD₅₀ of CMC-Na for female mice is 14 g/kg body weight of mice, equivalent to 9.8 g/kg body weight of rat, categorized as practically non-toxic according to Loomis criteria (LD₅₀ 5-15g/kg body weight of rat)^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9004-32-4

固体

White to off-white

羧甲基纤维素钠5000-15000

Room temperature in continental US; may vary elsewhere.

• [1]. Du XH, et al. Dexamethasone and sodium carboxymethyl cellulose prevent postoperative intraperitoneal adhesions in rats. Braz J Med Biol Res. 2015 Apr;48(4):344-8.  [Content Brief]

  [2]. Common Vehicles for Nonclinical Evaluation of Therapeutic Agents.

  [3]. Ida Musfiroh, et al. Toxicity Evaluation of Na-CMC synthesized from Cellulose of Water Hyacinth (Eichhornia crassipes (Mart.) Solms).ISSN: 0975-8585