1. GPCR/G Protein
  2. Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor 相关产品 (45):

Cat. No. Product Name Effect Purity
  • HY-10889
    Preladenant Antagonist 99.08%
    Preladenant 是一种有效的竞争性 A2A 受体拮抗剂,Ki 为 1.1 nM,比作用于其他腺苷受体选择性高100倍以上。
  • HY-10857
    Vipadenant Antagonist 98.28%
    Vipadenant 是 adenosine 受体拮抗剂,能够抑制 A2A 和 A1 的活性,Ki 值分别为 1.3 nM 和 68 nM。
  • HY-13201A
    CGS 21680 Hydrochloride Agonist 99.70%
    CGS 21680 Hydrochloride 是 adenosine A2A receptor 特异性激动剂,常用于神经疾病的研究。
  • HY-19532
    ZM241385 Antagonist 98.55%
    ZM241385是一种新型非黄嘌呤腺苷受体拮抗剂, 选择性拮抗A2A受体。
  • HY-10995
    Tozadenant Antagonist 98.06%
    Tozadenant 是 adenosine A2A 受体拮抗剂,作用于人类和恒河猴的 adenosine A2A 受体,Ki 值分别为 11.5 nM 和 6 nM。
  • HY-101980
    AZD4635 Inhibitor 98.85%
    AZD4635 是一种新型的腺苷 2A 受体 (A2AR) 抑制剂,其 Ki 值为 1.7 nM。
  • HY-100747
    PSB-12379 Inhibitor 99.54%
    PSB-12379 是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂,Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
  • HY-103173
    NECA Agonist 99.86%
    NECA 是一个非选择性的腺苷受体激动剂。
  • HY-B0809
    Theophylline Inhibitor 99.94%
  • HY-19533
    SCH 58261 Antagonist 99.38%
    SCH58261是adenosine A2A receptor竞争性的拮抗剂。
  • HY-10888
    Istradefylline Antagonist 99.42%
    Istradefylline 是一种有效的,选择性的,可口服的 adenosine A2A receptor 拮抗剂,在帕金森疾病模型试验中,Ki 值为 2.2 nM。
  • HY-A0168
    Regadenoson Agonist >98.0%
    Regadenoson是一种A 2A腺苷受体激动剂。
  • HY-14917
    Capadenoson Agonist 99.38%
    Capadenoson 是一种选择性的腺苷-A1受体 (adenosine-A1 receptor) 激动剂。
  • HY-101978
    CPI-444 Inhibitor 99.60%
    CPI-444 是一种有效的选择性 A2A 受体 (A2AR) 抑制剂,诱导抗肿瘤反应。
  • HY-13591
    IB-MECA Agonist 98.97%
    IB-MECA是一种腺苷A 3受体激动剂, EC50值为0.11 μM。
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor 99.20%
    Ticlopidine盐酸盐是ADP受体抑制剂,对血小板凝集的IC50为2 μM。
  • HY-12365
    2-Cl-IB-MECA Agonist 99.51%
    2-Cl-IB-MECA是一个选择性的 A3 adenosine 受体的激动剂,选择性分别是A1,A2的2500到1400倍。
  • HY-18939
    N6-Cyclohexyladenosine Agonist >98.0%
    N6-Cyclohexyladenosine是一种选择性的腺苷A1 受体激动剂 (EC50 = 8.2 nM)。
  • HY-B0128
    Diphylline Antagonist 99.28%
  • HY-18978
    GR79236 Agonist
    GR79236是一种高度有效的选择性腺苷A1受体激动剂 (Ki=3.1 nm), 具有镇痛和抗炎作用。