1. GPCR/G Protein
  2. Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor 相关产品 (48):

Cat. No. Product Name Effect Purity
  • HY-10889
    Preladenant Antagonist 99.08%
    Preladenant 是一种有效,竞争性的人腺苷 A2A 受体拮抗剂,Ki 为 1.1 nM,比其他腺苷受体选择性高100倍以上。
  • HY-13201A
    CGS 21680 Hydrochloride Agonist 99.70%
    CGS 21680 Hydrochloride是选择性的腺苷A2A受体激动剂,Ki为27 nM。
  • HY-19532
    ZM241385 Antagonist 98.55%
    ZM 241385是选择性和高亲和力的A2A腺苷受体拮抗剂。
  • HY-B0809
    Theophylline Inhibitor 99.94%
    Theophylline是非选择性的磷酸二酯酶 (PDE)抑制剂,腺苷受体阻断剂,和组蛋白脱乙酰酶 (HDAC)活化剂。
  • HY-19533
    SCH 58261 Antagonist 99.38%
    SCH58261是adenosine A2A receptor竞争性的拮抗剂。
  • HY-112840
    ST3932 Antagonist
    ST3932 是 ST1535 的代谢物,为 adenosine A2A 受体拮抗剂,对 A2A 和 A1 受体的 Ki 值分别为 8 nM 和 33 nM。
  • HY-112502
    MethADP Inhibitor
    MethADP 是一个特异性的 CD73 抑制剂。
  • HY-10857
    Vipadenant Antagonist 98.28%
    Vipadenant 是腺苷受体拮抗剂,抑制 A2A 和 A1 活性的 Ki 值分别为 1.3 nM 和 68 nM。
  • HY-101978
    CPI-444 Inhibitor 99.85%
    CPI-444 是一种有效的选择性 A2A 受体 (A2AR) 抑制剂,诱导抗肿瘤反应。
  • HY-10888
    Istradefylline Antagonist 99.42%
    Istradefylline 是一种有效的,选择性的,可口服的 adenosine A2A receptor 拮抗剂,在帕金森疾病模型试验中,Ki 值为 2.2 nM。
  • HY-10995
    Tozadenant Antagonist 98.06%
    Tozadenant 是 adenosine A2A 受体拮抗剂,作用于人类和恒河猴的 adenosine A2A 受体,Ki 值分别为 11.5 nM 和 6 nM。
  • HY-14917
    Capadenoson Agonist 98.43%
    Capadenoson 是一种选择性的腺苷-A1受体 (adenosine-A1 receptor) 激动剂。
  • HY-12365
    Namodenoson Agonist 99.51%
    2-Cl-IB-MECA是一个选择性的 A3 adenosine 受体的激动剂,选择性分别是A1,A2的2500到1400倍。
  • HY-101980
    AZD4635 Inhibitor 99.79%
    AZD4635 是一种新型的腺苷 2A 受体 (A2AR) 抑制剂,其 Ki 值为 1.7 nM。
  • HY-A0168
    Regadenoson Agonist >98.0%
    Regadenoson是一种A 2A腺苷受体激动剂。
  • HY-103173
    5'-N-Ethylcarboxamidoadenosine Agonist 99.86%
    NECA 是一个非选择性的腺苷受体激动剂。
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor 99.99%
    Ticlopidine盐酸盐是ADP受体抑制剂,对血小板凝集的IC50为2 μM。
  • HY-100747
    PSB-12379 Inhibitor 99.99%
    PSB-12379 是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂,Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
  • HY-18939
    N6-Cyclohexyladenosine Agonist 99.98%
    N6-Cyclohexyladenosine是一种选择性的腺苷A1 受体激动剂 (EC50 = 8.2 nM)。
  • HY-13591
    IB-MECA Agonist 98.97%
    IB-MECA是一种腺苷A 3受体激动剂, EC50值为0.11 μM。
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