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Aromatase

Aromatase (also known as CYP19) is a member of the general class of cytochrome P450 enzymes. It catalyzes the conversion of androgens to estrogens, which is a crucial step in the biosynthesis of estrogens in the human body.

Aromatase enzyme is expressed in ovarian granulosa cells, placental syncytiotrophoblast, adipose tissue, brain, and skin fibroblasts. The primary sources of aromatase are ovarian granulosa cells in premenopausal women and adipose cells in postmenopausal women. Aromatase inhibitors suppress oestrogen synthesis in the ovaries and in peripheral tissues, starting from the next day after dosing. They work by inhibiting the action of aromatase, which converts androgens into oestrogens (testosterone into estradiol and androstenedione into oestrone). There are three generations of aromatase inhibitors (AIs). Aminoglutethimide is a first-generation aromatase inhibitor. The second-generation inhibitors include Fadrozole and Formestane. Anastrozole, Letrozole, and Exemestane are third-generation inhibitors.

Aromatase is encoded by the cyp19a1 gene, belongs to a particular reticulum-bound cytochrome P450 superfamily and forms an electron-transfer complex with its partner, NADPH-cytochrome P450 reductase (CPR).

Aromatase 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-14248
    Letrozole Inhibitor 99.91%
    Letrozole(CGS-20267)是口服的非甾体芳香酶抑制剂。
  • HY-14274
    Anastrozole Inhibitor 99.79%
    Anastrozole 是一种选择性的芳香酶 (aromatase) 抑制剂,抑制胎盘芳香化酶,IC50 为 15 nM。
  • HY-13763
    Testolactone Inhibitor
    Testolactone是一种芳香酶抑制剂,是一种合成的抗肿瘤剂。
  • HY-B0697
    Formestane Inhibitor 99.87%
    Formestane(CGP-32349; 4-OHA)是I型芳香酶抑制剂。
  • HY-13632
    Exemestane Inhibitor
    Exemestane(FCE 24304)是芳香酶(aromatase)抑制剂,能抑制人胎盘和鼠卵巢芳香酶,IC50分别为30 nM和40 nM。
  • HY-B0237
    Aminoglutethimide Inhibitor
    Aminoglutethimide是芳香酶抑制剂,IC50为10 μM。