1. GPCR/G Protein
    Immunology/Inflammation
  2. CRTH2 (GPR44)

CRTH2 (GPR44)

Chemoattractant receptor homologous molecule of Th2 cells (CRTH2) has been shown to mediate the chemotaxis of eosinophils, basophils and Th2-type T lymphocytes. The major mast cell product prostaglandin (PG) D(2) is considered to be the principal ligand of CRTH2.

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. CRTh2 receptors, expressed on eosinophils, basophils, T-helper 2 cells, macrophages, and neutrophils are known to be involved in chemotaxis and activation of these cells, which form the key events initiating the inflammatory response in allergic diseases.

CRTH2 (GPR44) 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-16768
    Fevipiprant Antagonist 98.31%
    Fevipiprant(QAW039)是一种有选择性的,强有力的,可逆的竞争性拮抗剂。靶点为CRTh2受体,KD值为1.1 nM,IC50为0.44 nM,能够引发人体嗜酸性粒细胞的形状变化。
  • HY-15950
    AZD1981 Antagonist 99.52%
    AZD1981是CRTh2(DP2; GPR44)高效选择性抑制剂。