1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Fatty Acid Synthase (FAS)

Fatty Acid Synthase (FAS)

Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.

Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.

Fatty Acid Synthase (FAS) 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-12364
    C75 Inhibitor 99.86%
    C75是合成的脂肪酸合成酶(FASN)抑制剂; 抑制前列腺癌细胞PC3的IC50值为35 μM。
  • HY-A0210
    Cerulenin Inhibitor >99.0%
    Cerulenin 是一种广泛使用的天然脂肪酸合成酶 (FAS) 抑制剂。Cerulenin 是由真菌 Cephalosporium caeruleus 产生的。
  • HY-B0218
    Orlistat Inhibitor 99.75%
  • HY-12364A
    C75 trans Inhibitor 99.71%
    C75 trans是C75的对映异构体,C75是脂肪酸合成酶 (FASN) 的抑制剂。
  • HY-12648A
    FAS-IN-1 Tosylate Inhibitor 99.30%
    FAS-IN-1 Tosylate 是高效的脂肪酸合酶FAS抑制剂,来自专利WO 2012064642 A1化合物实例29,IC50值为10 nM。
  • HY-111551
    FT113 Inhibitor
    FT113 是一种有效、可口服的脂肪酸合酶 (fatty acid synthase (FASN)) 抑制剂,对全长重组人 FASN 酶的 IC50 值为 213 nM。在 BT474 细胞中,FT113 抑制 FASN 的活性,IC50 值为 90 nM。FT113 具有抗增殖作用,在体内和体外实验中,都具有抗癌作用。
  • HY-120062
    TVB-3664 Inhibitor
    TVB-3664 是具有口服活性的、可逆的、有效的、选择性的并具有高生物利用度的脂肪酸合酶 (FASN) 抑制剂,其对人和老鼠棕榈酸酯合成的 IC50 值分别为 18 nM 和 12 nM。可显著降低微管蛋白棕榈酰化和 mRNA表达。
  • HY-111777
    FASN-IN-1 Inhibitor
    FASN-IN-1 是一种脂肪酸合成酶 (FASN) 抑制剂, 详细信息请参考专利 WO2015134790A1,化合物 56。
  • HY-12648
    FAS-IN-1 Inhibitor
  • HY-112522A
    HS80 Inhibitor
    HS-80 是 Fasnall 的一种对映体,Fasnall 是一种选择性脂肪酸合酶 (FASN) 抑制剂。HS-80 能够抑制氚化乙酸盐掺入脂质中,IC50 为 7.13 μM。
  • HY-112522
    HS79 Inhibitor
    HS-79 是 Fasnall 的一种对映体,Fasnall 是一种选择性脂肪酸合酶 (FASN) 抑制剂。HS-79 能够抑制氚化乙酸盐掺入脂质中,IC50 为 1.57 μM。
  • HY-U00436
    FASN inhibitor 1 Inhibitor
    FASN inhibitor 1 是一种脂肪酸合酶 (FASN) 抑制剂,详细信息请参考专利文献 US20170119786A1 中的化合物 242A。
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