1. Metabolic Enzyme/Protease
  2. HIV Integrase

HIV Integrase

HIV Integrase is an enzyme produced by a HIV that enables its genetic material to be integrated into the DNA of the infected cell. IN is a key component in the retroviral pre-integration complex (PIC). All retroviral integrase proteins contain three canonical domains, connected by flexible linkers: an N-terminal HH-CC zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse transcriptase. The main function of IN is to insert the viral DNA into the host chromosomal DNA, a step that is essential for HIV replication. Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration is in part responsible for the persistence of retroviral infections.

HIV Integrase 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-13238
    Dolutegravir Inhibitor 99.54%
    Dolutegravir是第二代HIV整合酶链转移抑制剂 (INSTI),IC50 为 2.7 nM。
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir 是一种 HIV integrase 抑制剂,作用于 HIV-1IIIB,HIV-2EHO 和 HIV-2RODIC50 分别为 0.7 nM,2.8 nM 和 1.4 nM。
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.96%
    Raltegravir potassium salt 是一种有效的 integrase 抑制剂,用于治疗 HIV 感染。
  • HY-17605
    Bictegravir Inhibitor 98.27%
    Bictegravir 是一种新型,有效的 HIV-1 整合酶抑制剂,其 IC50 值为 7.5 nM。
  • HY-15592
    Cabotegravir Inhibitor 99.85%
    Cabotegravir是一种有效的HIV整合酶抑制剂, 用于治疗和预防艾滋病毒感染, Cabotegravir抑制OAT1 (IC50为0.81 μM) 和OAT3 (IC50为0.41 μM)。
  • HY-13238A
    Dolutegravir sodium Inhibitor
    Dolutegravir钠盐是HIV蛋白酶强效抑制剂,IC50值为2.7nM,对Raltegravir耐药突变型HIV毒株Y143R, Q148K, N155H,和G140S/Q148H也有一定的抑制作用。
  • HY-18595
    BI 224436 Inhibitor 98.17%
    BI 224436是一种新型的HIV-1非催化性位点整合酶抑制剂,对HIV-1实验室菌株的EC50值小于15 nM。
  • HY-18601
    (±)-BI-D Inhibitor
    (_plusmn_)-BI-D是HIV整合酶(integrase)变构抑制剂,作用于整合酶与LEDGF/p75结合部位。
  • HY-10522
    HIV-1 integrase inhibitor 2 Inhibitor 99.41%
    HIV-1 integrase inhibitor可作用于HIV感染。
  • HY-13269
    BMS-707035 Inhibitor 99.97%
    BMS-707035是HIV-1整合酶(IN)抑制剂,IC50为15 nM。
  • HY-13025
    HIV-1 integrase inhibitor Inhibitor 98.64%
    HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。
  • HY-B1408
    Salicylanilide Inhibitor 99.60%
    Salicylanilide 表现出广泛的生物学特性,包括通过抑制靶向 HIV-1 整合酶 (HIV-1 integrase) 或逆转录酶来抑制 HIV 病毒 (HIV virus) 的抗病毒效力。
  • HY-10353
    Raltegravir Inhibitor 98.11%
    Raltegravir(MK0518)是HIV整合酶(IN)抑制剂。
  • HY-11019
    BMS-538203 Inhibitor
    BMS-538203是高效的HIV整合酶抑制剂。
  • HY-13305
    MK-2048 Inhibitor
    MK-2048是HIV整合酶和INR263K的抑制剂,IC50分别为2.6 nM和1.5 nM。
  • HY-108820
    HIV-1 integrase inhibitor 4 Inhibitor
    HIV-1 integrase inhibitor 4 是一种 HIV-1 整合酶链转移 (INST) 抑制剂,其 IC50 值为 3.7 nM。
  • HY-108817
    HIV-1 integrase inhibitor 3 Inhibitor
    HIV-1 integrase inhibitor 3 是一种 HIV-1 整合酶链转移 (INST) 抑制剂,其 IC50 值为 2.7 nM。
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