1. GPCR/G Protein
    Neuronal Signaling
  2. Imidazoline Receptor

Imidazoline Receptor

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

Imidazoline Receptor 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-B0374
    Moxonidine Agonist 98.96%
    Moxonidine(BDF5895)是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
  • HY-B0374A
    Moxonidine hydrochloride Agonist
    Moxonidine(BDF5895)盐酸盐是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
  • HY-N0543
    Allantoin Agonist 98.36%
    Allantoin是促进皮肤健康,刺激新鲜健康组织生长的皮肤调理剂。
  • HY-101238
    Agmatine sulfate Agonist >98.0%
    Agmatine sulfate在多个靶点上发挥调节作用,如神经递质系统,离子通道,一氧化氮合成。它是 imidazoline receptor 的内源性激动剂和 NO synthase 抑制剂。