1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor

Melatonin Receptor

Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.

Melatonin Receptor 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-B0075
    Melatonin Activator >98.0%
    Melatonin 是产生于大脑的一种激素,为 melatonin 受体的激活剂,具有抗氧化、抗炎等活性。
  • HY-A0014
    Ramelteon Agonist 99.92%
    Ramelteon是高效选择性的melatonin受体激动剂,结合人melatonin1和melatonin2受体的Ki值分别为14 和112 pM。
  • HY-14803
    Tasimelteon Agonist 99.92%
    Tasimelteon是褪黑素MT1和MT2受体激动剂。
  • HY-103005
    Ramelteon metabolite M-II Activator
    Ramelteon metabolite M-II 是雷美替胺 (Ramelteon) 的主要代谢物,其对人褪黑素受体 1 和 2 的 IC50 值分别为 208 pM 和 1470 pM。雷美替胺是褪黑素受体 (melatonin) 的选择性激动剂。
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