1. Membrane Transporter/Ion Channel
  2. Sodium Channel

Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.

Sodium Channel 相关产品 (78):

Cat. No. Product Name Effect Purity
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride是D25HT2A钾通道钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。
  • HY-B0285A
    Amiloride hydrochloride Inhibitor >98.0%
    Amiloride (hydrochloride)是上皮钠通道 ENaC 抑制剂和尿激酶型纤溶酶原激活物的竞争性抑制剂 (uPA)。
  • HY-101840
    EIPA Inhibitor 99.73%
    EIPA 是一种 TRPP3 channel 抑制剂,其 IC50 值为 10.5 μM。EIPA 还抑制 Na+/H+ 交换器 (NHE) 和巨噬细胞的增多。
  • HY-B0246
    Carbamazepine Inhibitor 99.35%
    Carbamazepine是压敏钠离子通道阻断剂,IC50为 131 μM。
  • HY-B0211
    Riluzole Inhibitor 99.83%
    Riluzole 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,它也可以抑制 GABA 摄取,其 IC50 值为 43 μM。
  • HY-112279
    GNE-131 Inhibitor
    GNE-131 是人类钠离子通道 NaV1.7 (hNaV1.7) 有效的、选择性抑制剂,其 IC50 值为 3 nM。
  • HY-114301
    PF-06305591 Inhibitor
    PF-06305591 是一种有效的、高选择性的电压门控钠通道 NaV1.8 的阻断剂,其IC50 值为15 nM。具有良好的临床前体外ADME (吸收、分布、代谢和排泄) 和安全性[1]
  • HY-B1671
    (+)-Kavain 99.98%
    (+)-Kavain 是从卡瓦胡椒 (Piper methysticum) 中提取的一种主要的卡瓦内酯,具有抗惊厥作用,通过电压依赖性的Na+ 和Ca2+通道相互作用,减弱血管平滑肌的收缩[1]。Kavain 能与α4β2δ GABAA 受体结合,加强GABA的功效[2]。Kavain 是一种治疗炎症疾病的药物,其抗炎作用已被广泛研究[4]
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+hKv1.4 通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 NF-κB 活性和 COX-2 表达。
  • HY-19693
    Cariporide Inhibitor 98.57%
    Cariporide (HOE-642) 是选择性的 Na+/H+ 交换抑制剂。
  • HY-16738A
    Eleclazine hydrochloride Inhibitor 99.47%
    Eleclazine hydrochloride是一个新的Na+电流的抑制剂,IC50值是0.7 uM.
  • HY-15991
    Tenapanor Inhibitor 98.80%
    Tenapanor是钠氢离子 (Na+/H+) 交换NHE3的抑制剂, 抑制人和大鼠NHE3的IC50值分别为5和10 nM。
  • HY-12593
    GS967 Inhibitor 99.96%
    GS967 (GS-458967)是有效地选择性的心脏晚期钠电流抑制剂(late INa),在心室肌细胞和心脏中的IC50值分别为0.13和0.21 μM。
  • HY-B0575
    Triamterene Inhibitor 99.17%
    Triamterene是压敏型上皮钠离子通道(ENaC)阻断剂,有利尿作用。
  • HY-B0185
    Lidocaine Inhibitor 99.52%
    Lidocaine是组胺H1受体反向激动剂,IC50>32 μM。
  • HY-B0495
    Lamotrigine Inhibitor 99.94%
    Lamotrigine(BW430C)可抑制5-HT和钠离子通道,可作用于惊厥。
  • HY-12883
    PF 05089771 Inhibitor 99.32%
    PF 05089771是出自专利WO/2010/079443 A1中的Nav1.7离子通道阻断剂,IC50值8.6nM。
  • HY-17401
    Ranolazine dihydrochloride Inhibitor 99.92%
    Ranolazine双盐酸盐具有抗心律失常活性。
  • HY-B0448
    Phenytoin Inhibitor 99.91%
    Phenytoin是非活化的电压门控钠离子通道稳定剂。
  • HY-B0448A
    Phenytoin sodium Inhibitor 99.91%
    Phenytoin钠是一种非活性的电压-门控钠通道稳定剂。
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