1. Metabolic Enzyme/Protease
  2. Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA desaturase (SCD) is an integral membrane protein of the endoplasmic reticulum (ER) that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. Recent studies suggest that SCD is a key regulator of energy metabolism and has implications in dislipidemia and obesity. It is responsible for forming a double bond in Stearoyl-CoA. This is how themonounsaturated fatty acid oleic acid is produced from the saturated fatty acid stearic acid. Stearoyl-CoA desaturase is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction.

Stearoyl-CoA Desaturase (SCD) 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-50709
    A939572 Inhibitor 99.67%
    A939572 是一种口服有效的 SCD1 抑制剂,作用于 mSCD1hSCD1IC50 分别为 <4 nM 和 37 nM。
  • HY-15700
    PluriSIn 1 Inhibitor 99.64%
    PluriSIn 1 (NSC 14613) 是一种酰基-辅酶A去饱和酶 (SCD) 抑制剂,是一种多能细胞特异性的抑制剂。
  • HY-19762
    GSK1940029 Inhibitor 99.78%
    GSK1940029 是一种有效的酰基-辅酶A去饱和酶 (SCD) 抑制剂,详细信息请参考专利 WO/2009060053 A1 中的化合物 example 16。
  • HY-15823
    CAY10566 Inhibitor 99.01%
    CAY10566 是一种硬脂酰辅酶 A 去饱和酶 (SCD) 抑制剂。
  • HY-13070
    MK-8245 Inhibitor 99.39%
    MK-8245是肝靶向的硬脂酰-CoA去饱和酶(SCD)抑制剂,对人SCD1和鼠SCD1的IC50分别为1 nM和3 nM。
  • HY-11034
    CVT-12012 Inhibitor 98.97%
    CVT-12012 是一种有效的、具有口服活性的硬脂酰-CoA 去饱和酶 (SCD) 的抑制剂,其对大鼠微粒体和人 HEPG2 的 IC50 值分别为 38 nM,6.1 nM。
  • HY-102045
    T-3764518 Inhibitor
    T-3764518 是新颖高效的硬脂酰辅酶A去饱和酶 (SCD) 抑制剂,IC50 为4.7 nM。
  • HY-13077
    MK-8245 Trifluoroacetate Inhibitor 98.09%
    MK-8245三氟醋酸盐是肝靶向的硬脂酰-CoA去饱和酶(SCD)抑制剂,对人SCD1和鼠SCD1的IC50分别为1 nM和3 nM。
  • HY-100249
    XEN723 Inhibitor
    XEN723 是一种新型且有效的硬脂酰辅酶 A 去饱和酶 (SCD1) 的噻唑基咪唑烷酮抑制剂,在小鼠和 HepG2 细胞中的 IC50 值分别为 45 和 524 nM。
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