1. TGF-beta/Smad
  2. TGF-β Receptor

TGF-β Receptor

TGF-β (Transforming growth factor-β) receptors are single pass serine/threonine kinase receptors. TGF-β receptor exists in several different isoforms that can be homo- or heterodimeric. TGF is involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney,liver, and testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptor, can halt and in some cases reverse the effects of renal fibrosis. Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2.

TGF-β Receptor 相关产品 (27):

Cat. No. Product Name Effect Purity
  • HY-10431
    SB-431542 Inhibitor 98.79%
    SB-431542 是一种有效,选择性的 ALK5 抑制剂,IC50 值为 94 nM;同时也是转化生长因子 β 受体 (TGF-β Receptor) 抑制剂。
  • HY-13226
    LY2157299 Inhibitor 99.89%
    LY2157299 是一种选择性的 TGF-β 受体抑制剂,IC50 为 56 nM。
  • HY-10432
    A 83-01 Inhibitor >98.0%
    A 83-01 是有效的 ALK5ALK4ALK7 的抑制剂, IC50 值分别为 12,45 和 7.5 nM。
  • HY-12075
    LY2109761 Inhibitor 99.95%
    LY2109761是可口服,选择性的 TGF-β receptor type I/II 抑制剂,Ki分别为38 nM 和 300 nM。
  • HY-12071
    LDN193189 Inhibitor
    LDN193189是 BMP 信号传导抑制剂,抑制ALK1ALK2ALK3ALK6IC50分别为0.8,0.8,5.3,16.7 nM。
  • HY-112331
    SJ000291942 Inhibitor 99.20%
    SJ000291942 是经典骨形态发生蛋白 (BMP) 信号传导途径的激活剂。BMP 是转化生长因子 β (TGFβ) 分泌信号分子家族的成员。
  • HY-13012
    RepSox Inhibitor 99.94%
    RepSox 是一种有效,选择性的 TGFβR-1/ALK5 抑制剂, 抑制ALK5自磷酸化,IC50 为 4 nM。
  • HY-19928
    EW-7197 Inhibitor 99.12%
    EW-7197是 ALK5 的ATP竞争性抑制剂,IC50为12.9 nM。抑制ALK2和ALK4在纳摩尔级别。
  • HY-12043
    SB 525334 Inhibitor 99.45%
    SB 525334是一种有效,选择性的转化生长因子β1受体 (ALK5) 抑制剂,IC50 为 14.3 nM。
  • HY-12071A
    LDN193189 Hydrochloride Inhibitor 99.68%
    LDN193189 Hydrochloride是 BMP 信号传导抑制剂,抑制 ALK1ALK2ALK3ALK6IC50 分别为0.8,0.8,5.3,16.7 nM。
  • HY-13462
    LY-364947 Inhibitor 98.91%
    LY-364947 是一种有效的,ATP 竞争性的 TGFβR-I 抑制剂,IC50 值为 59 nM,是对 TGFβR-II 选择性的 7 倍。
  • HY-10432A
    A 83-01 sodium salt Inhibitor >98.0%
    A 83-01 sodium salt 是一种有效的 TGF-β I 型受体 ALK5,及 ALK4ALK7 抑制剂,能够抑制 ALK5,ALK4 和 ALK7 诱导的转录,IC50 值分别为 12,45 和 7.5 nM。
  • HY-13521
    SB-505124 Inhibitor 99.73%
    SB-505124 是一种选择性的 TGFβR 抑制剂,对 ALK4ALK5IC50 值分别为 129 nM 和 47 nM。
  • HY-12273
    DMH-1 Inhibitor 99.65%
    DMH-1 是一种有效的,具有选择性的 BMP 抑制剂,对 ALK1/ALK2/ALK3/ALK6的IC50 值分别为 27/107.9/<5/47.6 nM。
  • HY-10326
    GW788388 Inhibitor 99.84%
    GW788388 是一种有效的 ALK5 抑制剂,IC50 值 18 nM;同时抑制 TGF-β II 型受体 和激活素 II 型受体的活性,但对 BMP II 型受体无作用。
  • HY-103021
    LY3200882 Inhibitor 99.49%
    LY3200882 是一个新型且具有高选择性的 TGF-β 受体 1 型 (TGFβRI) 抑制剂。
  • HY-P0299
    LSKL, Inhibitor of Thrombospondin TSP-1 Inhibitor 98.29%
    LSKL, Inhibitor of Thrombospondin (TSP-1) 是一种四肽,源于潜在联系多肽,能够抑制 TSP-1 的活性,来降低 TGF-β 的活性,能够阻止肝损伤和肝纤维化。
  • HY-12704
    ITD-1 Inhibitor 98.66%
    ITD-1 是第一个选择性的 TGFβ 抑制剂,IC50 为 460 nM。
  • HY-15897
    LDN-212854 Inhibitor 99.24%
    LDN-212854是新型BMP抑制剂,对ALK2的IC50为1.3 nM,比对ALK1,ALK3,ALK4和ALK5的抑制性高2,66,1641和7135倍。
  • HY-12278
    K02288 Inhibitor 99.43%
    K02288 是 ALK 的高效抑制剂,能够有效抑制 ALK1,ALK2,ALK3,ALK6,IC50 值分别为 1.8 nM,1.1 nM,34.4 nM,6.3 nM;K02288 对 ALK4,ALK5 的抑制作用相对较弱,IC50 值分别为 302 nM 和 321 nM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.