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Thyroid Hormone Receptor

The thyroid hormone receptor (THR) is a type of nuclear receptor which belongs to a superfamily of eukaryotic transcription factors. It regulates gene expression in response to binding small, hydrophobic ligands. The receptors exhibits a modular structure, with functionally separable domains. The most highly conserved domains are the DNA-binding domain (DBD) and the ligand-binding domain (LBD). The DBD recognizes the specific DNA responses element for the receptor. The LBD participates in several activities, including hormone binding, homo- and/or heterodimerization, formation of heat-shock-protein complex, and transcriptional activation and repression. Unliganded thyroid hormone receptors are bound to DNA thyroid hormone response elements predominantly as homodimers, or as heterodimers with retinoid X-receptors, and are associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator. Hormone binding induces changes in receptor conformation that control these properties and influence gene expression.

Thyroid Hormone Receptor 相关产品 (14):

Cat. No. Product Name Effect Purity
  • HY-A0070A
    3,3',5-Triiodo-L-thyronine Activator 98.75%
    3,3',5-Triiodo-L-thyronine是有效的甲状腺激素受体 TRαTRβ 的激动剂,Ki 值为2.3 nM。
  • HY-14823
    Sobetirome Agonist >98.0%
    Sobetirome is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.
  • HY-12216
    MGL-3196 Agonist 99.43%
    MGL-3196是高度选择性的THR-β激动剂,EC50值为0.21 μM。
  • HY-A0070
    3,3',5-Triiodo-L-thyronine sodium Activator 98.16%
    3,3',5-Triiodo-L-thyronine sodium 是一种有效的甲状腺激素 (thyroid hormone),可以结合并激活 β1甲状腺激素受体 (TRβ1)。
  • HY-101406
    Thyroxine sulfate >98.0%
    Thyroxine sulfate是甲状腺激素代谢物。
  • HY-111443
    TR antagonist 1 Antagonist 99.64%
    TR antagonist 1是高亲和力的甲状腺激素受体 (thyroid hormone receptor (TR)) 拮抗剂,对 TRα 和 TRβ 的IC50 值分别为 36 和 22 nM。
  • HY-100856
    PCO371 Agonist
    PCO371 是一种可口服的甲状旁腺激素受体 1 (PTHR1) 的完全抑制剂,对 PTHR2 无作用。
  • HY-18341
    L-Thyroxine >98.0%
    L-Thyroxine (Levothyroxine; T4) 是一种合成的甲状腺激素,用于治疗甲状腺功能减退症。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
  • HY-B1201
    Tiratricol 98.02%
    Tiratricol是甲状腺激素类似物, 已被用来抑制垂体促甲状腺激素分泌, 降低垂体外拟甲状腺素药效。
  • HY-18341A
    L-Thyroxine sodium salt pentahydrate 99.85%
    L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) 是一种合成的甲状腺激素,用于治疗甲状腺功能减退症。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
  • HY-10473
    Eprotirome Agonist >98.0%
    Eprotirome 是一个肝脏选择性甲状腺激素受体激动剂。
  • HY-P0002A
    Protirelin Acetate Activator 99.58%
    Protirelin Acetate 是一种高度保守的神经肽,发挥促甲状腺激素 (TSH) 水平的激素控制作用,及神经调节功能。
  • HY-P0002
    Protirelin Activator
    Protirelin 是一种高度保守的神经肽,发挥促甲状腺激素 (TSH) 水平的激素控制作用,及神经调节功能。
  • HY-U00220
    KAT681 是一种肝脏选择性的拟甲状腺素剂。
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