1. Signaling Pathways
  2. GPCR/G Protein
  3. Amylin Receptor

Amylin Receptor (胰淀素受体)

AMYR

胰淀素受体 (AMYR) 是 G 蛋白偶联受体 (GPCR),对肽激素胰淀素和降钙素有反应。胰淀素最初被发现是 2 型糖尿病患者胰岛淀粉样蛋白沉积的主要成分,在糖尿病猫中,胰淀素也是一种生理相关的循环肽激素。胰淀素受体是异二聚体,由降钙素受体组成,降钙素受体是一种 G 蛋白偶联受体,也是三种受体修饰蛋白之一。功能研究的一个障碍是很难将胰淀素受体表型与降钙素受体表型区分开来。胰淀素受体是治疗肥胖症和代谢紊乱的靶点。

Amylin receptors (AMYRs) are G protein-coupled receptors (GPCRs), which respond to the peptide hormones amylin and calcitonin. Amylin was originally discovered as the main constituent of pancreatic islet amyloid deposits in type 2 diabetics and in diabetic cats, amylin is also a physiologically relevant circulating peptide hormone. Amylin receptors are heterodimers comprising the calcitonin receptor, which is a G protein–coupled receptor, and one of three receptor-modifying proteins. An impediment to functional studies is that it is difficult to separate amylin receptor phenotypes from calcitonin receptor phenotypes. Amylin receptors are targets for treating obesity and metabolic disorders.

Amylin Receptor 相关产品 (26):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1871
    Amylin (IAPP), feline
    Amylin (IAPP), feline 是来源于猫科动物的含有 37 个氨基酸的多肽。Amylin (IAPP), feline 是胰岛 β 细胞的主要分泌产物之一。Amylin (IAPP), feline 是一种调节肽,可抑制胰岛素和胰高血糖素的分泌。
    Amylin (IAPP), feline
  • HY-P3926
    Amylin (8-37) (human)
    Amylin (8-37) (human) (hIAPP (8-37)) 是人胰岛淀粉样多肽 (IAPP) 的 8-37 片段。Amylin (8-37) 组装中的双重折叠结构具有发夹结构。
    Amylin (8-37) (human)
  • HY-P4785
    Acetyl-Amylin (8-37) (human) Antagonist
    Acetyl-Amylin (8-37) (human) 是特异性的 amylin 拮抗剂。
    Acetyl-Amylin (8-37) (human)
  • HY-P991249
    NI-203 Inhibitor
    NI-203 是一种单克隆抗体抑制剂,靶向 amylin。NI-203 有望用于 2 型糖尿病的研究。
    NI-203
  • HY-P4767
    Amylin (1-13) (human) Ligand
    Amylin (1-13) (human) 是人胰淀素(IAPP)淀粉样蛋白核心内的片段和残基。胰淀素是一种葡萄糖调节激素,在 II 型糖尿病 (T2D) 情况下以淀粉样纤维形式沉积。Amylin (1-13) (human) 对纤维形成没有影响,因为它本身不能形成纤维。
    Amylin (1-13) (human)
  • HY-P0058A
    Pramlintide TFA

    普兰林肽三氟乙酸盐

    Pramlintide TFA 是一种人胰淀粉样多肽类似物。Pramlintide 是一种抗糖尿病剂,也可用于肠癌的研究。
    Pramlintide TFA