1. GPCR/G Protein
    Neuronal Signaling
  2. CGRP Receptor
  3. β-CGRP, human TFA

β-CGRP, human TFA (Synonyms: Human β-CGRP (TFA); CGRP-II (Human) (TFA))

目录号: HY-P1548A 纯度: 98.82%
产品使用指南

β-CGRP, human TFA 是一种降钙素肽,通过降钙素受体样受体 CRLRRAMP 的复合物起作用,在细胞体系中,对 CRLR/RAMP1 和 CRLR/RAMP2 的 IC50 值分别为 1 nM 和 300 nM。

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Custom Peptide Synthesis

β-CGRP, human TFA Chemical Structure

β-CGRP, human TFA Chemical Structure

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Size Price Stock Quantity
500 μg ¥1800 In-stock
1 mg ¥3100 In-stock
5 mg ¥11000 In-stock
10 mg   Get quote  
50 mg   Get quote  

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Description

β-CGRP, human TFA is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells[1].

IC50 & Target

IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay)[1]

In Vitro

β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2[1]. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity[2].

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (12.80 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2559 mL 1.2796 mL 2.5593 mL
5 mM 0.0512 mL 0.2559 mL 0.5119 mL
10 mM 0.0256 mL 0.1280 mL 0.2559 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
References
Molecular Weight

3907.38

Formula

C₁₆₄H₂₆₈F₃N₅₁O₅₀S₃

Sequence

Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2(Disulfide bridge: Cys2-Cys7)

Sequence Shortening

ACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF-NH2(Disulfide bridge: Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
β-CGRP, human TFA
目录号:
HY-P1548A
需求量:

β-CGRP, human TFA

Cat. No.: HY-P1548A