2. Anti-infection
  3. Bacterial
  4. AAA-10 formic

AAA-10 formic 是一种具有口服活性的肠道细菌胆盐水解酶 (BSH) 抑制剂，对B. theta rBSH 和 B. longum rBSH 的 IC50 值分别为 10 nM, 80 nM。

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AAA-10 formic Chemical Structure

AAA-10 formic Chemical Structure

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AAA-10 formic 的其他形式现货产品:

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AAA-10 formic 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively[1].

IC50 & Target

IC50: 10 nM (B. theta rBSH), 80 nM (B. longum rBSH)[1]
体外研究
(In Vitro)

AAA-10 (100 μM; 24 h) formic inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively[1].
AAA-10 (20 μM; 2 h) formic significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates of human feces[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AAA-10 formic 相关抗体:
体内研究
(In Vivo)

AAA-10 (30 mg/kg; orally gavage daily for 5 days) formic decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces starting in day 2-5[1].
AAA-10 (30 mg/kg) formic displays high colonic exposure and low gut permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-11 weeks old male C57Bl/6J mice[1]
Dosage: 30 mg/kg
Administration: Orally gavaged once daily for 5 days
Result: Decreased the abundances of DCA and LCA in mice feces starting in day 2-5.
Displayed high colonic exposure and low gut permeability.
分子量

518.68

Formula

C26H43FO7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AAA-10 formic 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAA-10AAA10AAA 10BacterialbacteriaHep-G2 cellsCaco-2 cellsmicefecesInhibitorinhibitorinhibit

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产品名称：
AAA-10 formic
目录号：
HY-145147A
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