2. Neuronal Signaling
  3. Sigma Receptor
  4. AB10

AB10 是选择性 S1R 拮抗剂。AB10 对 S1R 和 S2R 的 Ki 分别为 10 和 165 nM。AB10 能够逆转Capsaicin (HY-10448) 对模型造成的疼痛影响。

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AB10 Chemical Structure

AB10 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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Customer Review

AB10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AB10 is a selective S1R antagonist. AB10 with Ki of 10, 165 nM for S1R and S2R, respectively. AB10 reverses the effect of Capsaicin (HY-10448) caused pain in model[1].

IC50 & Target[1]

Sigma 1 Receptor

10 nM (Ki)

Sigma 2 Receptor

165 nM (Ki)

体内研究
(In Vivo)

AB10 （20mg/kg，s.c.，在注射辣椒素前30分钟给药） 诱发S1R拮抗剂效应逆转疼痛，并表现出比 BD-1063 （HY-18101A） 更高的效力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Capsaicin-induced as a pain model in CD1 mice[1]
Dosage: 20 mg/kg
Administration: subcutaneous injection performed in different areas of the interscapular zone, administered 30 min before the injection of Capsaicin (HY-10448).
Result: Achieved similar effects at half the concentration of BD-1063 (HY-18101A) (40mg/kg).
Showed complete reversal of the mechanical hypersensitivity reaction.
分子量

334.50

Formula

C23H30N2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AB10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB10AB 10AB-10Sigma ReceptorS1R antagonistCapsaicin-induced mechanical hypersensitivity.Inhibitorinhibitorinhibit

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目录号：
HY-149855
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