2. Membrane Transporter/Ion Channel Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. ATP-binding cassette (ABC) transporters LXR
  4. ABCA1 inducer 2

ABCA1 inducer 2 是一种非促脂性 ABCA1 诱导剂。ABCA1 inducer 2 通过靶向 LXR 通路上调 ABCA1 的表达，可减少 ox-LDL 诱导的脂质蓄积，从而抑制泡沫细胞形成。ABCA1 inducer 2 具有抗动脉粥样硬化潜力。

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ABCA1 inducer 2 Chemical Structure

ABCA1 inducer 2 Chemical Structure

CAS No. : 2451589-46-9

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ABCA1 inducer 2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential[1].

体外研究
(In Vitro)

ABCA1 inducer 2 (Compound 3) (0.01-10 μM, 24 h) 在 Hela 细胞中有很强的 ABCA1 启动子激活能力 [1]。
ABCA1 inducer 2 (0.01-10 μM, 18 h) 在 RAW 264.7 细胞中有效诱导 ABCA1 mRNA 的表达，且呈剂量依赖性，在 10 μM 时最大增加量为对照的 3.94 倍[1]。
ABCA1 inducer 2 (0.01-10 μM, 12-48 h) 在 RAW 264.7 细胞和 Hela 细胞中作用于 LXR 通路来上调 ABCA1 蛋白表达[1]。
ABCA1 inducer 2 (10 μM, 24 h) 在 RAW 264.7 细胞中能够有效的降低 ox-LDL 诱导的细胞内脂质蓄积，抑制泡沫细胞的形成[1]。
ABCA1 inducer 2 (10 μM, 48 h) 在 HepG2 细胞中诱导有限的脂质和甘油三酯积累，减少与高甘油三酯血症和肝脏脂肪生成相关的副作用[1]。
ABCA1 inducer 2 (0.01-10 μM, 24 h) 在 10 μM 浓度下对 Hela，RAW264.7 和 HepG2 细胞均无显著毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABCA1 inducer 2 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 0.01-10 μM
Incubation Time: 12-48 h
Result: At a concentration of 10 μM, ABCA1 protein expression in RAW 264.7 cells increased, with a maximum response time of 24 to 48 hours.
Significantly upregulated ABCA1 expression in a dose-dependent manner within the concentration range of 0.01 to 10 μM.
Completely depended on the LXR pathway for the activation of ABCA1, as GSK2033 completely blocked this effect.
分子量

327.18

Formula

C16H11BrN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABCA1 inducer 2 相关分类

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Keywords:

ABCA1 inducer 22451589-46-9ATP-binding cassette (ABC) transportersLXRATP-binding cassette transportersLiver X receptorABCA1Macrophage foam cellsatherosclerosisHepG2 cellsInhibitorinhibitorinhibit

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