1. Protein Tyrosine Kinase/RTK
  2. Anaplastic lymphoma kinase (ALK)
  3. ALK-IN-21

ALK-IN-21 (Compound B10) 是一种有效的 ALK 抑制剂,对 ALKWT、ALKL1196M 和 ALKG1202RIC50 值分别为 4.59 nM、2.07 nM 和 5.95 nM。ALK-IN-21 有效抑制 ALK 阳性的 Karpas299 和 H2228 细胞增殖,IC50 值都为 0.07 μM。ALK-IN-21 可用于间变性大细胞淋巴瘤的研究。

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ALK-IN-21 Chemical Structure

ALK-IN-21 Chemical Structure

CAS No. : 2901889-01-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 μM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1].

IC50 & Target

IC50: 2.07 nM (ALKL1196M), 4.59 nM (ALKWT), 5.95 nM (ALKG1202R)[1]

体外研究
(In Vitro)

ALK-IN-21 (Compound B10) inhibits the proliferation of Karpas299, H2228 and HCT116 cells with IC50 values of 0.07, 0.07 and 5.53 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

809.48

Formula

C35H45ClN6O6S4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ALK-IN-21
目录号:
HY-146408
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