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  4. Alloc-Val-Ala-OH

Alloc-Val-Ala-OH  (Synonyms: ((Allyloxy)carbonyl)-L-valyl-L-alanine)

目录号: HY-W076556
产品使用指南 技术支持

Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) 是合成 Tesirine 的构建块，Tesirine 是一种临床抗体-药物偶联物 (ADC) 吡咯并苯二氮卓 (PBD) 二聚体有效载荷。Val-Ala 将被组织蛋白酶 B 特异性切割。Alloc 基团对哌啶和 TFA 处理稳定，但可在温和条件下通过钯催化烯丙基转移轻松去除。

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Alloc-Val-Ala-OH Chemical Structure

Alloc-Val-Ala-OH Chemical Structure

CAS No. : 330970-70-2

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规格 价格 是否有货 数量
250 mg ￥130
In-stock
500 mg ￥210
In-stock
1 g ￥340
In-stock
5 g ￥850
In-stock
10 g ￥1365
In-stock
25 g ￥2731
In-stock
50 g   询价  

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Alloc-Val-Ala-OH 相关抗体

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  • 生物活性

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生物活性

Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

分子量

272.30

同用名

((Allyloxy)carbonyl)-L-valyl-L-alanine

Formula

C12H20N2O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

Alloc-Val-Ala-OH 相关分类

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  • 稀释计算器

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Keywords:

Alloc-Val-Ala-OH330970-70-2((Allyloxy)carbonyl)-L-valyl-L-alanineBiochemical Assay ReagentsInhibitorinhibitorinhibit

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