2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. Anti-MRSA agent 28

Anti-MRSA agent 28 是一种针对多药耐药革兰氏阳性菌株的抗菌剂，其 MIC 为 0.06-0.125 μg/mL。Anti-MRSA agent 28 能够靶向 DNA 聚合酶 IIIC 减少基因组 DNA 数量，IC50 为 3.80 μg/mL。Anti-MRSA agent 28 具有良好的抗菌活性并且可以减少炎症。Anti-MRSA agent 28 可用于抗革兰氏阳性菌株和感染性疾病[1]。

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Anti-MRSA agent 28 Chemical Structure

Anti-MRSA agent 28 Chemical Structure

CAS No. : 2222727-47-9

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Anti-MRSA agent 28 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-MRSA agent 28 is an antibacterial agent against multidrug resistant (MDR) gram-positive strains with MICs of 0.06-0.125 μg/mL. Anti-MRSA agent 28 can target DNA polymerase IIIC to reduce the amount of genomic DNA with the IC50 of 3.80 μg/mL. Anti-MRSA agent 28 has good antibacterial activity and reduces inflammation. Anti-MRSA agent 28 can be used against gram-positive strains and infectious conditions[1].

体外研究
(In Vitro)

Anti-MRSA agent 28 (Compound 5a) 对革兰氏阳性菌株显示出抗菌活性，包括金黄色葡萄球菌 ATCC 33591 (MIC = 0.125 μg/mL)、ATCC 700698 (MIC = 0.125 μg/mL)、ATCC 700699 (MIC = 0.06 μg/mL) 和 ATCC BAA1708 (MIC = 0.125 μg/ mL)[1]。

Anti-MRSA agent 28 (0.25 μg/mL-4 μg/mL；0 小时-24 小时) 对金黄色葡萄球菌 ATCC 33591 具有抗菌活性[1]。

Anti-MRSA agent 28 (1 μg/mL；1 小时) 可能抑制基因组 DNA 的功能障碍[1]。

Anti-MRSA agent 28 (0.5 μg/mL-4.5 μg/mL) 有效地影响基因组 DNA 的数量[1]。

Anti-MRSA agent 28 (6.25 μM -50 μM) 可以剂量依赖性地与 DNA Pol-IIIC 结合，其 KD 值为 8.45 μM[1]。

Anti-MRSA agent 28 (0 μg/mL -16 μg/mL) 抑制金黄色葡萄球菌 ATCC 33591 的 DNA Pol-IIIC[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 28 相关抗体:
体内研究
(In Vivo)

Anti-MRSA agent 28 (2 % 凡士林；每天一次；持续 3 天) 可显著减少细菌数量并降低全身炎症，同时有效缓解感染组织的坏死和中性粒细胞的浸润和积聚[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The infection model was constructed by adding a droplet (20 μL) of 9 lg10 CFU/mL of S. aureus ATCC 33591 on the wound surface of the female BALB/c mouse (8 weeks)[1].
Dosage: 2 % in vaseline
Administration:
Result: Significantly lowered serum levels of pro-inflammatory cytokines: interleukin IL-1β, IL-6, TNF-α and C-reactive protein and effectively alleviated the necrosis.
分子量

503.93

Formula

C27H22ClN3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-MRSA agent 28 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MRSA agent 282222727-47-9BacterialDNA/RNA SynthesisMRSADNA polymerase IIICantibacterialinfectionInhibitorinhibitorinhibit

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