Antibacterial agent 271 

Antibacterial agent 271 is an antibacterial agent with significant inhibition against Escherichia coli (MIC: 2.2 μM). Antibacterial agent 271 reduces metabolic activity by disrupting the integrity of bacterial membranes. Antibacterial agent 271 binds to DNA grooves to inhibit replication and induces accumulation of reactive oxygen species (ROS) , ultimately leading to bacterial death. Antibacterial agent 271 shows significant potential in combating bacterial infections^[1].

Antibacterial agent 271 (Compound 11c) 对大肠杆菌的抑制效果突出 (MIC: 2.2 μM)， 对其他革兰氏阴性菌 (铜绿假单胞菌 MIC: 17.6 μM) 部分革兰氏阳性菌 (金黄色葡萄球菌 MIC: 8.8 μM和粪肠球菌 MIC: 4.4 μM) 表现出较强的抑制作用^[1]。
Antibacterial agent 271 (2.2 μM-8.8 μM, 4 h) 在 2.2 μM 时即可完全抑制细菌生长，表明其具有良好的快速抑制大肠杆菌生长的能力^[1]。
Antibacterial agent 271 在大肠杆菌中经过 16 代传代实验 MIC 值仍保持稳定，展示了耐药性风险低的特点^[1]。
Antibacterial agent 271 (0.5632 mM, 24 h) 在人红细胞 (RBC) 中表现出低溶血活性的特点^[1]。
Antibacterial agent 271 (40 μM) 对人正常肝细胞 (LO2) 和乳腺癌细胞 (MCF-7) 的细胞毒性极低 (细胞存活率 > 85%)^[1]。
Antibacterial agent 271 (2.2 μM -35.2 μM) 对大肠杆菌造成膜电位失衡，外膜破坏，内膜损伤以及蛋白泄露的作用^[1]。
Antibacterial agent 271 (2.2 μM -35.2 μM) 抑制大肠杆菌代谢活性使得细胞活力丧失，并且诱导大肠杆菌中的 ROS 产生，从而抑制细菌生长^[1]。
Antibacterial agent 271 (2.2 μM -35.2 μM) 通过沟槽结合 (groove binding) 与 DNA 相互作用，抑制复制但不切割 DNA，最终破坏细菌的正常生物学功能^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

455.44

C₂₀H₁₇N₅O₆S

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang YX, et al. Benzo-α-pyrone-derived multitargeting actions to enhance the antibacterial performance of sulfanilamides against Escherichia coli. Bioorg Chem. 2025 May;158:108339.  [Content Brief]