2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 195

Anticancer agent 195 (Compound 10) 是 ELF3-MED23 PPI 抑制剂，Ki 为 0.68 μM。Anticancer agent 195 诱导细胞凋亡 (apoptosis)，具有抗肿瘤活性。

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Anticancer agent 195 Chemical Structure

Anticancer agent 195 Chemical Structure

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Anticancer agent 195 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity[1].

IC50 & Target

>Ki: 0.68 μM (ELF3-MED23 PPI)
体外研究
(In Vitro)

Anticancer agent 195 (10 μM) 阻断 ELF3-MED23 相互作用，抑制 HER2 启动子的活性以及 AKT 和 MAPK 磷酸化[1]。
Anticancer agent 195 (10 μM) 在 NCI-N87 细胞中具有抗增殖和诱导凋亡的活性，可以对抗曲妥珠单抗的耐药性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 195 相关抗体:

Western Blot Analysis[1]

Cell Line: NCI-N87, NCI-N87 TR
Concentration: 0-10 μM
Incubation Time: 16 h
Result: Reduced levels of HER2, phosphorylated AKT and p-MAPK.
Increased cleaved PARP and c-caspase 3.

Apoptosis Analysis[1]

Cell Line: NCI-N87, NCI-N87 TR
Concentration: 0-15 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.
体内研究
(In Vivo)

Anticancer agent 195 (4 mg/kg，静脉注射 25 天) 抑制无胸腺 NCI-N87 异种移植裸鼠体内的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-N87 xenograft athymic nude mice[1]
Dosage: 4 mg/kg
Administration: i.v., every three days for 25 days
Result: Inhibited tumor growth.
分子量

412.48

Formula

C24H28O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 195 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 195Anticancer agent195Anticancer agent-195Apoptosisgastric cancerHER2NCI-N87trastuzumab resistanceTRNCI-N87 TRathymic nude miceInhibitorinhibitorinhibit

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