2. Apoptosis
  3. Apoptosis Ferroptosis
  4. Anticancer agent 199

Anticancer agent 199 (Compound G-4) 通过抑制 EGFR、AKT 和 MAPK 途径，以及线粒体途径诱导三阴性乳腺癌 (TNBC) 细胞凋亡 (Apoptosis)。Anticancer agent 199 还通过下调 LCN2 诱导铁死亡 (Ferroptosis)。Anticancer agent 199 抑制 TNBC 细胞活力和迁移，并诱导 S 期细胞周期停滞。Anticancer agent 199 是细胞周期蛋白依赖性激酶抑制剂 Rocovitine 的衍生物。

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Anticancer agent 199 Chemical Structure

Anticancer agent 199 Chemical Structure

CAS No. : 2422001-24-7

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Anticancer agent 199 相关抗体

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生物活性

Anticancer agent 199 (Compound G-4) induces apoptosis in triple negative breast cancer (TNBC) cells via the mitochondrial pathway through inhibiting EGFR, AKT and MAPK pathways. Anticancer agent 199 also induces Ferroptosis by down-regulating LCN2. Anticancer agent 199 inhibits TNBC cell viability and migration, and induces S phase cell cycle arrest. Anticancer agent 199 is a derivate of cyclin-dependent kinase inhibitor Rocovitine[1].

分子量

556.12

Formula

C29H39ClFN7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 199 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Anticancer agent 1992422001-24-7Anticancer agent199Anticancer agent-199ApoptosisFerroptosisTNBCbreast canceranticancerRocovitineInhibitorinhibitorinhibit

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