Anticancer agent 83

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Anticancer agent 83 是一种强效抗癌剂，抑制 LOX IMVI 细胞生长的 GI₅₀ 为 0.15 mM。Anticancer agent 83 能够降低线粒体膜电位，并诱导 DNA 损伤，以诱导白血病细胞凋亡 (apoptosis)。

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Anticancer agent 83 Chemical Structure

CAS No. : 904815-29-8

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生物活性
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参考文献

生物活性

Anticancer agent 83 is a potent anticancer agent, inhibits LOX IMVI cells growth with a GI₅₀ value of 0.15 mM. Anticancer agent 83 reduces mitochondrial membrane potential and induces DNA damage to induces leukemia cells apoptosis^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human A549 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
BALB/3T3	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HaCaT	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human HaCaT cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HaCaT cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HCT-116	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HCT-116	GI₅₀	8.4 μM Compound: 4a	Antiproliferative activity against p53-deficient human HCT-116 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against p53-deficient human HCT-116 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HEK293	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human HEK293 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HEK293 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HeLa	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human HeLa cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
HL-60(TB)	GI₅₀	2.8 μM Compound: 4a	Antiproliferative activity against human HL-60(TB) cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human HL-60(TB) cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
HOP-92	GI₅₀	2.85 μM Compound: 4a	Antiproliferative activity against human HOP-92 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human HOP-92 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
Jurkat	GI₅₀	0.69 μM Compound: 4a	Antiproliferative activity against human Jurkat cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human Jurkat cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
K562	GI₅₀	5.4 μM Compound: 4a	Antiproliferative activity against human K562 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human K562 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
KB 3-1	GI₅₀	7.4 μM Compound: 4a	Antiproliferative activity against human KB 3-1 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human KB 3-1 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
LOX IMVI	GI₅₀	0.15 μM Compound: 4a	Antiproliferative activity against human LOX IMVI cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human LOX IMVI cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
MCF7	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human MCF7 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
MDA-MB-231	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
NCI-H460	IC₅₀	28 nM Compound: 4a	Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
NCI-H522	GI₅₀	1.97 μM Compound: 4a	Antiproliferative activity against human NCI-H522 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human NCI-H522 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
RXF 393	GI₅₀	4.27 μM Compound: 4a	Antiproliferative activity against human RXF 393 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human RXF 393 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
SF-295	GI₅₀	2.71 μM Compound: 4a	Antiproliferative activity against human SF-295 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human SF-295 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
SK-OV-3	GI₅₀	10 μM Compound: 4a	Antiproliferative activity against human SK-OV-3 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human SK-OV-3 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
SR	GI₅₀	1.77 μM Compound: 4a	Antiproliferative activity against human SR cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human SR cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
THP-1	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human THP-1 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human THP-1 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]
TK-10	GI₅₀	3.21 μM Compound: 4a	Antiproliferative activity against human TK-10 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human TK-10 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
UO-31	GI₅₀	2.88 μM Compound: 4a	Antiproliferative activity against human UO-31 cells incubated for 48 hrs and measured by SRB assay Antiproliferative activity against human UO-31 cells incubated for 48 hrs and measured by SRB assay	[PMID: 35973342]
WM793	GI₅₀	> 100 μM Compound: 4a	Antiproliferative activity against human WM793 cells incubated for 72 hrs and measured by MTT assay Antiproliferative activity against human WM793 cells incubated for 72 hrs and measured by MTT assay	[PMID: 35973342]

体外研究
(In Vitro)

Anticancer agent 83 (compound 4a) (0.01-100 μM; 24 h) showing strong activity towards human colon carcinoma HCT116 p53^−/− cells with deletion of P53 gene (GI₅₀=8.4 μM), human epidermoid cervix carcinoma KB3-1 (GI₅₀=7.4 μM), human ovarian carcinoma Skov 3 cells (GI₅₀=10 μM), and human chronic myelogenous leukemia K562 cells (GI₅₀=5.4 μM)^[1].
Anticancer agent 83 (0.5 μM; 24 h) interrupts DNA stability and induction of apoptosis in Jurkat cells, and decreases mitochondrial membrane potential^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human colon carcinoma HCT116 p53−/− cells with deletion of P53 gene, human epidermoid cervix carcinoma KB3-1, human ovarian carcinoma Skov 3 cells, and human chronic myelogenous leukemia K562 cells
Concentration:	0.01, 0.1, 1, 10, 100 μM
Incubation Time:	24 hours
Result:	Inhibited cell viability in different cells with GI₅₀s of 8.4 M (HCT116 p53^−/−), 7.4 M (KB3-1), 10 M (Skov 3), and 5.4 M (K562), respectively.

Immunofluorescence^[1]

Cell Line:	Jurkat cells
Concentration:	0.5 μM
Incubation Time:	24 hours
Result:	Induced morphological changes (including apoptotic bodies, membrane blebbing, chromatin condensation), and DNA fragmentation in Jurkat T-cells.

分子量

377.46

Formula

C₂₀H₁₉N₅OS

CAS 号

904815-29-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Pokhodylo N, et al. Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells. Eur J Med Chem. 2022 Nov 5;241:114633. [Content Brief]

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摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 83904815-29-8Anticancer agent83Anticancer agent-83Apoptosismitochondrial membrane potentialDNA damageleukemia cellJurkat T-cellsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

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