2. Anti-infection
  3. Parasite
  4. Antimalarial agent 49

Antimalarial agent 49 是一种口服抗疟化合物。Antimalarial agent 49 可抑制 Pf3D7 和 PfK1 菌株的生长 (IC50 分别为 0.84 μM 和 0.4 μM)。Antimalarial agent 49 具有抗疟活性，并抑制 P. berghei 肝阶段的发育。Antimalarial agent 49 可用于疟原虫感染的研究。

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Antimalarial agent 49 Chemical Structure

Antimalarial agent 49 Chemical Structure

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Antimalarial agent 49 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection[1].

体外研究
(In Vitro)

Antimalarial agent 49 (compound 15k) (0.37-10 μM, 40 小时) 抑制 P. berghei 肝阶段的发育 (IC50: 5.88 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 49 相关抗体:
体内研究
(In Vivo)

Antimalarial agent 49 (compound 15k) (100 mg/kg，口服，每天1次，4天) 可抑制小鼠 P.yoelii N67 感染模型中寄生虫的生长 (35.93%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss mice (6-8-week-old, 18 ± 2 g) were intra-peritoneally inoculated with 1x106 P.yoelii N67 infected red blood cells (iRBCs)[1]
Dosage: 100 mg/kg
Administration: Oral gavage (p.o.), once every day for 4 d
Result: Inhibited 42.55% of parasite growth on the 7th day and 35.93% of parasite growth on the 10th day.
Prolonged the median survival time (17 d) compared with the Chloroquine (HY-17589A) (10 mg/kg)-treated group (16 d).
分子量

530.48

Formula

C28H18F4N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 49 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 49Antimalarial agent49Antimalarial agent-49ParasiteAntimalarialHepG2 cellsmouse P. yoelii N67 infection modelpasmodium infectionInhibitorinhibitorinhibit

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目录号：
HY-173312
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