2. Anti-infection
  3. Parasite
  4. Antimalarial agent 50

Antimalarial agent 50 是一种抗疟原虫化合物。Antimalarial agent 50 在小鼠模型中对伯氏疟原虫诱导的疟疾感染具有作用。Antimalarial agent 50 可以调节氧化应激并显著降低炎症因子的水平。Antimalarial agent 50 可用于疟疾的研究[1]。

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Antimalarial agent 50 Chemical Structure

Antimalarial agent 50 Chemical Structure

CAS No. : 2384242-67-3

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规格 是否有货
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100 mg   询价  
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Antimalarial agent 50 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

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  • 参考文献

生物活性

Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria[1].

体内研究
(In Vivo)

Antimalarial agent 50 (Compound 3a) (200-800 μg/kg；腹腔注射；每天一次；持续4天) 可以剂量依赖性地减少疟疾寄生虫感染的小鼠模型中的寄生虫感染，并且具有抗炎和抗氧化潜力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei NK 65 strain injected male Balb/c mice model (6-8 weeks)[1].
Dosage: 200-800 μg/kg, Positive control group Chloroquine (HY-17589A)
Administration: Intraperitoneal injection (i.p.)
Result: Showed the best anti parasitemia effect at 800 µg/kg with the inhibition rate of 83.6 %.
Restored RBCs similar to the vehicle control group.
Improved the condition of the ruffled fur and anxiety.
Significantly reversed RBCs, Hb, PCV, MCV, MCH, MCHC and platelets of infected mice.
Significantly reduced the concentration of AST, ALP, ALT and bilirubin, creatinine, uric acid and improved the pathological structure of the liver and spleen.
Improved the concentration of GSH, GST and CAT and reduced the concentration of NO and MDA.
Restored blood sugar levels in the infected mice.
Reduced the level of inflammatory factors NF-κB, IL-6, IFN-γ and decreased the level of the TNF-α, iNOS, IL-1β
分子量

410.49

Formula

C24H18N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 50 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 502384242-67-3Antimalarial agent50Antimalarial agent-50ParasiteAntimalarials Plasmodium bergheiParasitemiaInflammationOxidative stressInhibitorinhibitorinhibit

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