2. Neuronal Signaling
  3. Amyloid-β
  4. Antioxidant agent-8

Antioxidant agent-8 是一种具有口服活性的 Aβ1-42 沉积抑制剂。Antioxidant agent-8 抑制原纤维聚集 (IC50=11.15 µM)，促进原纤维分解 (IC50=6.87 µM)。Antioxidant agent-8 也抑制 Cu2+ 诱导的 Aβ1-42 原纤维聚集 (IC50=3.69 µM)，促进 Cu2+ 诱导的 Aβ1-42 原纤维分解 (IC50=3.35 µM)。Antioxidant agent-8 具有抗氧化活性、抗炎活性、生物安全性、血脑屏障通透性和神经保护作用。

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Antioxidant agent-8 Chemical Structure

Antioxidant agent-8 Chemical Structure

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Antioxidant agent-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antioxidant agent-8 is an orally active inhibitor of Aβ1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 µM) and promotes fibril disaggregation (IC50=6.87 µM). Antioxidant agent-8 also inhibits Cu2+-induced Aβ1-42 fibril aggregation (IC50=3.69 µM) and promotes Cu2+-induced Aβ1-42 fibril disaggregation (IC50=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect[1].

体外研究
(In Vitro)

Antioxidant agent-8 (compound 30) (50 µM；24 h) 选择性的与 Cu2+、 Fe2+、Zn2+、Fe3+ 和 Al3+ 金属离子螯合，显著抑制自身和 Cu2+ 诱导的 Aβ1-42 原纤维聚集和分解[1]。
Antioxidant agent-8 (2.5、5 和 10 µM；24 h) 促进 BV-2 细胞清除 Aβ1-42，减少了 Aβ1-42 诱导的细胞凋亡，以浓度依赖性的方式保护神经[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antioxidant agent-8 相关抗体:

Western Blot Analysis[1]

Cell Line: Mouse microglia BV-2 cells.
Concentration: 2.5, 5 and 10 µM.
Incubation Time: 24 h.
Result: Reduced the expression level of Aβ1-42 in cells.

Apoptosis Analysis[1]

Cell Line: Mouse microglia BV-2 cells.
Concentration: 2.5, 5 and 10 µM.
Incubation Time: 24 h.
Result: Significantly reduced Aβ1-42 induced apoptosis (cell apoptosis rate were below 30%).

Cell Viability Assay[1]

Cell Line: Mouse microglia BV-2 cells.
Concentration: 2.5, 5 and 10 µM.
Incubation Time: 24 h.
Result: Promoted cell viability and the cell survival was 75.50 % (10 µM).
体内研究
(In Vivo)

Antioxidant agent-8 (compound 30) (15 mg/kg；腹腔注射；单剂量) 显示出血脑通透性并在海马体中聚集[1]。
Antioxidant agent-8 (2000 mg/kg；腹腔注射；单剂量) 显示出生物安全性[1]。
Antioxidant agent-8 (20 mg/kg；口服给药；每天一次，持续 25 天) 显著改善了由东莨菪碱 (HY-N0296) 引起的焦虑、记忆缺陷、认知缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1].
Dosage: 15 mg/kg.
Administration: Intragastric administration; single dose.
Result: Appeared in plasma and hippocampus at 0.083, 0.167, 0.25, 0.5, 1, 2 and 4 hours after administration, and then gradually gathered in hippocampus.
Animal Model: Mice[1].
Dosage: 2000 mg/kg.
Administration: Intragastric administration; single dose.
Result: Showed insignificant toxic and side effects on heart, liver, spleen and brain.
Animal Model: SCOP-induced cognitive impairment in ICR mice (25-28 g)[1].
Dosage: 20 mg/kg.
Administration: Oral gavage; from day 7 to day 31, after 30 min of SCOP administration.
Result: Improved animal behavior, learning and memory.
分子量

248.23

Formula

C13H12O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antioxidant agent-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antioxidant agent-8Antioxidant agent8Antioxidant agent 8Amyloid-ββ-amyloid peptideAβAbetaBV-2 cellsMiceOrallyInhibitorinhibitorinhibit

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