2. Cell Cycle/DNA Damage Cytoskeleton
  3. DNA/RNA Synthesis Microtubule/Tubulin
  4. Antiproliferative agent-64

Antiproliferative agent-64 (Compound 76) 是真核翻译起始因子 4E (eIF4E) 的抑制剂，可阻断 mRNA 的二级结构，从而抑制蛋白质翻译。Antiproliferative agent-64 抑制 c-Myc 的 5' 非翻译区 (c-myc 5'UTR)，EC50 为 1.2 nM，抑制编码微管蛋白的 5'UTR (tub 5'UTR)，EC50 为 40 nM。Antiproliferative agent-64 抑制 MDA-MB-231 的增殖，EC50 为 7 nM。

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Antiproliferative agent-64 Chemical Structure

Antiproliferative agent-64 Chemical Structure

CAS No. : 1139263-21-0

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Antiproliferative agent-64 相关抗体

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生物活性

Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM[1].

分子量

500.54

Formula

C29H28N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-64 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antiproliferative agent-641139263-21-0Antiproliferative agent64Antiproliferative agent 64DNA/RNA SynthesisMicrotubule/TubulinNOD/SCID mouseRPMI-8226MDA-MB-231Inhibitorinhibitorinhibit

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