1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP ditromethamine

ATP ditromethamine  (Synonyms: Adenosine 5'-triphosphate ditromethamine)

目录号: HY-B2176D
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ATP ditromethamine (Adenosine 5'-triphosphate ditromethamine) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。ATP ditromethamine 是免疫和炎症中重要的内源性信号分子。

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ATP ditromethamine Chemical Structure

ATP ditromethamine Chemical Structure

CAS No. : 102047-34-7

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ATP ditromethamine 的其他形式现货产品:

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MCE 顾客使用本产品发表的 79 篇科研文献

WB
Cell Viability Assay
RT-PCR

    ATP ditromethamine purchased from MCE. Usage Cited in: Immunity. 2024 Mar 12;57(3):495-512.e11.  [Abstract]

    Representative western blots and analyses of the following proteins in BV2 cells treated with vehicle (Con), LPS (200 ng/ml, 3 h), LPS + ATP (3 mM, 30 min), or LPS + ATP-siNKAα1 (one experiment, n = 3). Supernatant (Sup) IL-1β (P17) and cellular lysates (Lys) pro-IL-1β; (I) supernatant caspase-1 (P20) and lysates pro-caspase-1.

    ATP ditromethamine purchased from MCE. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.

    ATP ditromethamine purchased from MCE. Usage Cited in: Cell Death Differ. 2021 Sep 11.  [Abstract]

    Primary BMDM cells were isolated from WT and Trim21-/- C57BL/6 mice. Cells were primed with 1 μg/mL LPS for 2 h followed by 5 mM ATP or 20 μM Nig or 30 μM flagellin for 30 min. Cell viability are determined by the Cell Counting Kit-8.

    ATP ditromethamine purchased from MCE. Usage Cited in: Crit Care. 2021 Oct 12;25(1):356.  [Abstract]

    Stimulation of Raw264.7 macrophages with PBS/PBS-Exo/TNF-Exo for 24 h and treatment with PBS, 5 mM ATP or 20 mM nigericin for 2 h. Cleavage of GSDMD by western blot. GSDMD-FL: full-length GSDMD, GSDMD-N: N-terminal cleavage products of GSDMD.

    ATP ditromethamine purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132.   [Abstract]

    KCs were transfected with lnc-Lfar1 siRNA for 24 h, followed by stimulation with 100 ng/ml LPS for 4 h and subsequently treated with 5 mM ATP or 100 ng/ml for 2 h to induce pyroptosis. a, b The protein level of NLRP3, Caspase1 and GSDMD was determined by western blot. GAPDH was used as an internal control.

    ATP ditromethamine purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132.   [Abstract]

    KCs and BMMs were stimulated with 100 ng/mL LPS for 4 hours and subsequently treated them with 5 mM ATP or 100 ng/mL for 2 hours to induce pyroptosis. The RNA level of lnc-Lfar1 was determined by qRT-PCR.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    ATP ditromethamine (Adenosine 5'-triphosphate ditromethamine) is a central component of energy storage and metabolism in vivo. ATP ditromethamine provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP ditromethamine is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    Clinical Trial
    分子量

    749.45

    同用名

    Adenosine 5'-triphosphate ditromethamine

    Formula

    C18H38N7O19P3

    CAS 号
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    The dilution calculator equation

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    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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