2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Avotaciclib sulfate

Avotaciclib sulfate  (Synonyms: BEY1107 sulfate)

目录号: HY-137432D
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Avotaciclib (BEY1107) sulfate 是一种口服有效的细胞周期蛋白依赖性激酶 1 (CDK1) 抑制剂。Avotaciclib sulfate 能够抑制肿瘤细胞增殖，诱导细胞凋亡 (apoptosis)。Avotaciclib sulfate 可用于胰腺癌、肺癌等肿瘤的研究。

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Avotaciclib sulfate Chemical Structure

Avotaciclib sulfate Chemical Structure

CAS No. : 1983984-04-8

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Avotaciclib sulfate 的其他形式现货产品:

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Other Forms of Avotaciclib sulfate:

Avotaciclib sulfate 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avotaciclib (BEY1107) sulfate is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib sulfate can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib sulfate can be used in the research of cancer such as pancreatic cancer and lung cancer[1][2].

IC50 & Target[1]

CDK1

 

体外研究
(In Vitro)

Avotaciclib (0-64 μM; 48 小时) sulfate 在具有放射治疗抗性的非小细胞肺癌细胞系中，可抑制细胞增殖并促进细胞凋亡，与 PV-1019 (HY-125203) 联用效果更好[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Avotaciclib sulfate 相关抗体:

Cell Viability Assay[2]

Cell Line: Non-small cell lung cancer cells (H1437R, H1568R, H1703R and H1869R)
Concentration: 0, 0.1, 1, 2, 4, 8, 16, 32 and 64 μM
Incubation Time: 48 h
Result: Inhibited the cell viability, with EC50 values of 0.918, 0.580, 0.735 and 0.662 μM for H1437R, H1568R, H1703R and H1869R, respectively.
Clinical Trial
分子量

379.35

Formula

C13H13N7O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Avotaciclib sulfate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avotaciclib1983984-04-8BEY1107BEY 1107BEY-1107CDKApoptosisCyclin dependent kinaseorallyactivecyclindependentkinasecancerNon-small cell lung cancer cells (H1437RH1568RH1703R and H1869R)Inhibitorinhibitorinhibit

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目录号：
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