Bleomycin A5 hydrochloride  (Synonyms: Pingyangmycin hydrochloride)

Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death^[1][2][3][4]..

1477.02

C₅₇H₉₀ClN₁₉O₂₁S₂

55658-47-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang LC, et al. MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med. 2004;33(1):37-45.  [Content Brief]

  [2]. Wu F, et al. Bleomycin A5 suppresses Drp1 mediated mitochondrial fission and induces apoptosis in human nasal polyp derived fibroblasts. Int J Mol Med. 2021;47(1):346-360.  [Content Brief]

  [3]. Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14(7):975-982.  [Content Brief]

  [4]. He Y, et al. Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway. Molecules. 2016;21(7):862. Published 2016 Jun 30.  [Content Brief]