2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Butamirate

Butamirate 是一种口服镇咳药，通过脑干受体中枢作用。Butamirate 还能通过抑制支气管痉挛和抗炎作用来降低气道阻力。Butamirate 可抑制胶质母细胞瘤 (GBM) 的生长和 STAT3 活性。Butamirate 可用于胶质母细胞瘤的研究。

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Butamirate Chemical Structure

Butamirate Chemical Structure

CAS No. : 18109-80-3

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规格 价格 是否有货 数量
5 mg ￥400
3 - 4 周
10 mg ￥640
3 - 4 周
25 mg ￥1280
3 - 4 周
50 mg ￥2000
3 - 4 周
100 mg ￥3200
3 - 4 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Butamirate:

Butamirate 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma[1][2].

体外研究
(In Vitro)

Butamirate (0.01-10 μM；7 天) 可有效抑制肿瘤球形成和 STAT3 活性[2]。
Butamirate 可有效抑制 RRAD 与 pSTAT3 的相互作用[2]。
Butamirate 在 U87MG 中显示 EGFR、STAT3、ERK 和 AKT 磷酸化降低[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Butamirate 相关抗体:

Cell Viability Assay[2]

Cell Line: U87MG, U87MG-TMZ-resistant (U87 TMZR), U87MG-Lapatinib-resistant (U87 LAPAR) and T98G (TMZ resistant) tumorspheres
Concentration: 0.01-10 μM
Incubation Time: 7 days
Result: Effectively suppressed growth of glioblastoma cell lines, including U87MG-TMZR and U87MG-LAPAR.
体内研究
(In Vivo)

Butamirate (2 mg/kg；腹膜内注射) 可抑制胶质母细胞瘤异种移植小鼠模型中的肿瘤生长，且无显著不良反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice (6- to 8 week-old) were subcutaneously injected with U87MG cells[2]
Dosage: 2 mg/kg
Administration: i.p; once a day; for 36 days.
Result: Inhibited tumor growth in a glioblastoma mouse xenograft model.
Clinical Trial
分子量

307.43

Formula

C18H29NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Butamirate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butamirate18109-80-3STATbronchial diseasescoughbronchospasmanti-inflammatoryInhibitorinhibitorinhibit

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目录号：
HY-118545
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