2. Others Apoptosis
  3. Isotope-Labeled Compounds Apoptosis
  4. C6 Ceramide-13C2,d2

C6 Ceramide-13C2,d2  (Synonyms: C6-Cer-13C2,d2; N-Hexanoylsphingosine-13C2,d2)

目录号: HY-W766368
产品使用指南 技术支持

C6 Ceramide-13C2,d2 (C6-Cer-13C2,d2) 是 13C 和氘代标记的 C6 Ceramide (HY-19542)。C6-ceramide (C6-Cer) 是一种短链、能够透过细胞的神经酰胺途径激活剂，具有抗癌活性。C6-ceramide 介导的 miR-29b 表达通过靶向 Akt信号通路，参与多发性骨髓瘤的进展，抑制血管内皮细胞的增殖、迁移和血管生成。C6-ceramide 展现出多种抗癌特性，包括细胞周期停滞、凋亡 (Apoptosis)、抑制肿瘤生长，以及增强化疗对耐药癌细胞的效果。C6-ceramide 可以作为化疗剂的辅助剂，以增强抗肿瘤效果。

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C6 Ceramide-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub> Chemical Structure

C6 Ceramide-13C2,d2 Chemical Structure

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C6 Ceramide-13C2,d2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

C6 Ceramide-13C2,d2 (C6-Cer-13C2,d2) is the deuterium labeled and 13C-labeled C6 Ceramide (HY-19542). C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2][3][4][5].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C6 Ceramide-13C2,d2 相关抗体:
分子量

401.63

同用名

C6-Cer-13C2,d2; N-Hexanoylsphingosine-13C2,d2

Formula

C2213C2H45D2NO3
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

C6 Ceramide-13C2,d2 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C6 Ceramide-13C2,d2C6-Cer-13C2,d2 N-Hexanoylsphingosine-13C2,d2Isotope-Labeled CompoundsApoptosisInhibitorinhibitorinhibit

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