2. GPCR/G Protein Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. Angiotensin Receptor PPAR
  4. Candesartan

Candesartan (GMP) (CV 11974 (GMP)) 是 GMP 级别的 Candesartan (HY-B0205)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Candesartan 是一种血管紧张素 II AT1-受体 (angiotensin II AT1-Receptor) 阻滞剂和 PPAR-γ 激动剂，具有口服活性。Candesartan 具有强效和持久的抗高血压作用。Candesartan 可用于高血压、慢性心力衰竭 (CHF) 和创伤性脑损伤 (TBI) 的研究。

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Candesartan Chemical Structure

Candesartan Chemical Structure

CAS No. : 139481-59-7

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Candesartan 的其他形式现货产品:

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Candesartan 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Candesartan (GMP) (CV 11974 (GMP)) is Candesartan (HY-B0205) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].

体内研究
(In Vivo)

Candesartan (GMP) (腹腔注射；1 mg/kg/天；持续 1、3 或 28 dpi) 具有神经保护作用，可减少神经元损伤、减少损伤体积和小胶质细胞活化、保护 CBF 并改善 TBI 小鼠模型的功能行为[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (nine-week-old, male, 22-28 g)[3]
Dosage: 1 mg/kg
Administration: i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi.
Result: Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGFß1 while increasing expression of TGFB3.
Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
分子量

440.45

同用名

CV 11974

Formula

C24H20N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Candesartan 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candesartan (GMP)139481-59-7CV 11974 (GMP)Angiotensin ReceptorPPARPeroxisome proliferator-activated receptorsoralangiotensin II AT1-ReceptorPPAR-γantihypertensivehypertensionhronic heart failure (CHF)Traumatic brain injury (TBI)Inhibitorinhibitorinhibit

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