2. Protein Tyrosine Kinase/RTK Apoptosis
  3. c-Met/HGFR Apoptosis
  4. Capmatinib dihydrochloride hydrate (Standard)

Capmatinib dihydrochloride hydrate (Standard)  (Synonyms: 卡马替尼盐酸盐水合物 (Standard))

目录号: HY-13404CR 纯度: ≥98%
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Capmatinib (dihydrochloride hydrate) (Standard） 是 Capmatinib (dihydrochloride hydrate) 的分析标准品。本产品用于研究及分析应用。Capmatinib (INC280; INCB28060) dihydrochloride hydrate 是一种有效的、口服活性的、选择性的、ATP 竞争性的 c-Met 激酶抑制剂 (IC50=0.13 nM)。Capmatinib dihydrochloride hydrate 可抑制 c-MET 的磷酸化，以及 c-MET 通路下游效应蛋白如 ERK1/2、AKT、FAK、GAB1 和 STAT3/5。Capmatinib dihydrochloride hydrate 有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移，并有效诱导细胞凋亡。在肿瘤小鼠模型中表现出抗肿瘤活性。Capmatinib dihydrochloride hydrate 主要由 CYP3A4 和醛氧化酶代谢。

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Capmatinib dihydrochloride hydrate (Standard) Chemical Structure

Capmatinib dihydrochloride hydrate (Standard) Chemical Structure

CAS No. : 1865733-40-9

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生物活性

Capmatinib (dihydrochloride hydrate) (Standard) is the analytical standard of Capmatinib (dihydrochloride hydrate). This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase.

分子量

503.36

同用名

卡马替尼盐酸盐水合物 (Standard)

Formula

C23H21Cl2FN6O2
CAS 号
中文名称

卡马替尼盐酸盐水合物 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Capmatinib dihydrochloride hydrate (Standard) 相关分类

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Keywords:

Capmatinib dihydrochloride hydrate (Standard)1865733-40-9卡马替尼盐酸盐水合物 (Standard)c-Met/HGFRApoptosisorally activeATP competitiveSNU-5S114H441U-87MGBalb/c nu/nu miceInhibitorinhibitorinhibit

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