2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. CB7993113

CB7993113 是一种有效的 AHR 拮抗剂，IC50 为 0.33 μM。 CB7993113 直接结合 AHR 蛋白并阻断 AHR 核转位。 CB7993113 可分别抑制多环芳烃 (PAH) 和 TCDD 诱导的报告基因活性 75% 和 90%。

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CB7993113 Chemical Structure

CB7993113 Chemical Structure

CAS No. : 819827-50-4

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CB7993113 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively[1].

体外研究
(In Vitro)

当以至少高达 20 μM 的浓度添加到多种人类细胞（包括 HepG2 肝癌细胞、BP1、D3、Hs578T 或 MDA-MB-231 乳腺癌细胞以及原代人诱导多能干细胞）时，CB7993113 不会表现出毒性 [1]。
CB7993113 显着降低 ER-/PR-/HER2- 乳腺癌细胞的体外侵袭表型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CB7993113 相关抗体:
体内研究
(In Vivo)

CB7993113 可有效阻断 50 mg/kg DMBA (HY-W011845) 诱导的急性肝 CYP1A1 诱导和体内骨髓毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

364.15

Formula

C15H10BrNO5
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CB7993113 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB7993113819827-50-4CB 7993113CB-7993113Aryl Hydrocarbon ReceptorAhRInhibitorinhibitorinhibit

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