2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK12-IN-8

CDK12-IN-8 (Compound Cpd143) 是一种具有口服活性，高选择性的细胞周期蛋白依赖性激酶 12 (CDK12) 抑制剂。CDK12-IN-8 抑制 CDK12 对 RNA 聚合酶 II C 端结构域 (CTD) 丝氨酸 2 的磷酸化，干扰基因转录延伸和 DNA 损伤修复通路。CDK12-IN-8 有望用于 CDK12 高表达癌症的研究，如小细胞肺癌和三阴性乳腺癌。

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CDK12-IN-8 Chemical Structure

CDK12-IN-8 Chemical Structure

CAS No. : 2928619-86-5

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CDK12-IN-8 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer[1].

IC50 & Target

CDK12

 

分子量

459.42

Formula

C21H20F3N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK12-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK12-IN-82928619-86-5CDKCyclin dependent kinaseorally activeCDK12RNA polymerase IIcancersInhibitorinhibitorinhibit

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