1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK4/6-IN-2

CDK4/6-IN-2 

目录号: HY-114339
产品使用指南

CDK4/6-IN-2 是一种有效的 CDK4CDK6 抑制剂,IC50 分别为 2.7 和 16 nM,详细信息请参考专利文献 US20180000819A1 中 的化合物 1。

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CDK4/6-IN-2 Chemical Structure

CDK4/6-IN-2 Chemical Structure

CAS No. : 1800506-48-2

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3901 In-stock
5 mg ¥3500 In-stock
10 mg ¥5500 In-stock
50 mg ¥16500 In-stock
100 mg ¥26500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1].

IC50 & Target[1]

CDK4

2.7 nM (IC50)

CDK6

16 nM (IC50)

In Vitro

CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5.2 mg/mL (10.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9740 mL 9.8699 mL 19.7398 mL
5 mM 0.3948 mL 1.9740 mL 3.9480 mL
10 mM 0.1974 mL 0.9870 mL 1.9740 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.52 mg/mL (1.03 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.52 mg/mL (1.03 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 0.52 mg/mL (1.03 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

506.59

Formula

C₂₇H₃₂F₂N₈

CAS No.

1800506-48-2

SMILES

CCN1CCN(CC2=CN=C(NC3=NC=C(F)C(C4=CC(N(C(C)C)C(C)=N5)=C5C(F)=C4)=C3)N=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CDK4/6-IN-2
目录号:
HY-114339
需求量:

CDK4/6-IN-2

Cat. No.: HY-114339