2. Cell Cycle/DNA Damage JAK/STAT Signaling Apoptosis
  3. CDK Pim Apoptosis
  4. CDK6/PIM1-IN-1 hydrochloride

CDK6/PIM1-IN-1 hydrochloride 

目录号: HY-142696A 纯度: 99.38%
COA 产品使用指南 技术支持

CDK6/PIM1-IN-1 (Compound 51) hydrochloride 是一种具有口服活性且有效的双重 CDK6/PIM1 抑制剂，IC50 值分别为 39 nM 和 88 nM。CDK6/PIM1-IN-1 hydrochloride 抑制 CDK4 (IC50=3.6 nM)。CDK6/PIM1-IN-1 hydrochloride 可显著抑制急性髓系白血病 (AML) 细胞增殖，将细胞周期阻滞在 G1 期，并促进细胞凋亡 (apoptosis)。CDK6/PIM1-IN-1 hydrochloride 具有抗 AML 活性。

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CDK6/PIM1-IN-1 hydrochloride Chemical Structure

CDK6/PIM1-IN-1 hydrochloride Chemical Structure

CAS No. : 2677026-15-0

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Other Forms of CDK6/PIM1-IN-1 hydrochloride:

CDK6/PIM1-IN-1 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 Pim 亚型特异性产品:

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PIM1 PIM2 PIM3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 hydrochloride inhibits CDK4 (IC50=3.6 nM). CDK6/PIM1-IN-1 hydrochloride significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].

IC50 & Target

CDK6

39 nM (IC50)

PIM1

88 nM (IC50)

CDK4

3.6 nM (IC50)

分子量

510.01

Formula

C25H29ClFN9
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

CDK6/PIM1-IN-1 hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK6/PIM1-IN-12677026-15-0CDKPimApoptosisCyclin dependent kinasePim kinasesacute myeloid leukemiaAMLG1 phaseK562HL-60MOLM13 cellInhibitorinhibitorinhibit

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目录号：
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