1. Protein Tyrosine Kinase/RTK Apoptosis
  2. Bcr-Abl Apoptosis
  3. CHMFL-ABL-121

CHMFL-ABL-121 是一种 II 型 ABL 激酶高效抑制剂,抑制纯化的非活性 ABL wt 和 T315I 激酶蛋白的 IC50 值分别为 2 nM 和 0.2 nM。

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CHMFL-ABL-121 Chemical Structure

CHMFL-ABL-121 Chemical Structure

CAS No. : 2270879-07-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].

IC50 & Target[1]

ABL wt

2 nM (IC50)

ABL-T315I

0.2 nM (IC50)

体外研究
(In Vitro)

CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50<10 nM), MEG-01 (EC50<10 nM) and KU812 (EC50<30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1].
CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

580.67

Formula

C30H31F3N6OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

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产品名称:
CHMFL-ABL-121
目录号:
HY-119370
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